Tuesday, October 7, 2008

IGF-1 - more on insulin-like growth factor 1 - longevity connection

More on IGF-1 - a complicated picture is emerging as you'll see by the following articles. Part of the problem might be that IGF-1 appears to influence more than 800 genes and every cell in our body. So tease that apart for a hobby.

Shorter Women May Have Very Long Lives: Gene Mutation Found: ScienceDaily (Mar. 4, 2008)"the female children of the centenarians had IGF-I plasma levels that were 35 percent higher than female controls--perhaps a sign that the body was compensating for a glitch in IGF-I signaling by secreting increased amounts of the hormone. That suspicion was strengthened by two other findings: the daughters of centenarians were 2.5 cm shorter than female controls; and when the researchers analyzed the gene coding for the IGF-I cell-surface receptor molecule to which the IGF-I hormone binds, the receptor genes of centenarians and their daughters were much more likely to have a variety of mutations than were the receptor genes of the controls..."Our findings suggest that, by interfering with IGF-I signaling, these gene mutations somehow play a role in extending the human life span, as they do in many other organisms,"..."

Hormone May Hold Key To Helping Elderly Men Live Longer: "ScienceDaily (May 28, 2008) — Elderly men with higher activity of the hormone IGF-1--or insulin-growth factor 1--appear to have greater life expectancy and reduced cardiovascular risk"

Study Shows New Method Of Growth Hormone Dosing Improves Height: ScienceDaily June 7, 2005,"'We feel confident that IGF-based growth hormone dosing could become a novel paradigm in treating growth hormone deficiency, resulting in improved height increases for these children. The growth hormone dose targeted to achieve the higher IGF-I level produced especially meaningful increases in height compared to conventional weight-based methods of determining doses,'"

Deficiency Of Growth Hormone And IGF-1 Reduces Cancer And Kidney Disease, But Creates Other Problems: "ScienceDaily (Apr. 7, 2005) — WINSTON-SALEM, N.C. – Deficiencies of growth hormone and similar compounds may reduce cancer and kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning ability"

Growth Factor Signals Influence Balance Between Normal Growth And Cancerous Growth: ScienceDaily (Nov. 10, 2006) "So it is with the body's delicate concentration of growth factors. Too much of a signaling protein called insulin-like growth factor-I (IGF-I) may fan the flames of cancer, while too little of the protein may cause short stature, dementia and osteoporosis, among other problems."

Study Raises Questions About Prostate Cancer Therapies Targeting IGF-1: "ScienceDaily (May 1, 2008) — Therapies under development to treat prostate cancer by inhibiting the ability of insulin-like growth factor (IGF-1) to activate its target receptor could have unexpected results especially if a major tumor suppressor gene -- p53 -- is already compromised"

Growth Factor Predicts Poor Outcome In Breast Cancer: "ScienceDaily (Aug. 29, 2008) — The response to insulin-like growth factor 1 (IGF-I) in breast cancer cells predicts an aggressive tumor that is less likely to respond to treatment"

Why Elite Rowers Have Bigger, Stronger Hearts: "Elite rowers were found to have higher levels of insulin-like growth factor 1 (IGF-1) compared to healthy sedentary volunteers. In these athletes, IGF-1 values correlate with enlargement and strengthening of heart muscle cells."

Growth Hormone Found To Have New Role In Development Of Brain's Smell Center: "ScienceDaily (Mar. 27, 2008) — A human hormone known to stimulate the growth of cells throughout the body has a new role - helping to set up the proper nerve connections in the odor center of the brain"

Green Tea Polyphenols Thwart Prostate Cancer Development At Multiple Levels: "'Consumption of GTP led to reduced levels of IGF-1,'"

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