Thursday, November 27, 2008

IP6 articles

Antioxidants Could Provide All-purpose Radiation Protection: "ScienceDaily (Nov. 5, 2007) — Two common dietary molecules found in legumes and bran could protect DNA from the harmful effects of radiation, researchers from the University of Maryland report. Inositol and inositol hexaphosphate (IP6) protected both human skin cells and a skin cancer-prone mouse from exposure to ultraviolet B (UVB) radiation, the damaging radiation found in sunlight, the team reported November 5 at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine..."Both of these potent antioxidants have been shown to have broad-spectrum anti-tumor capabilities, and now our studies confirm the degree to which these molecules protect against the DNA-damaging effects of ionizing radiation"...While both inositol and IP6 are related to B vitamins, they are not considered essential dietary nutrients. In the 1980s, however, researchers discovered that these molecules, abundant within the hulls of seeds and grains, had definitive protective effects against colorectal cancer...According to Shamsuddin, IP6 could also offer protection against accidents or purposeful incidents involving nuclear material. "It could also be advisable to use IP6 plus inositol as a cautionary treatment following a nuclear disaster or dirty bomb,""

New Research On Cancer-fighting Foods, Supplements: ScienceDaily (Mar. 26, 2007)"The compound, inositol hexaphosphate (IP6), was fed to animal models of prostate cancer and resulted in up to a 66 percent reduction in tumor size in comparison to control animals"

Natural Substances Shows Promise In Cancer Prevention, Treatment: ScienceDaily (June 8, 1998)"cancer-fighting properties of inositol hexaphosphate (IP6) in colon, liver, breast and soft-tissue cancers in human cell-lines transplanted into mice..."The number of tumors and their size was reduced three-fold," Shamsuddin said. "The rate of cell division was cut in half. IP6 also normalizes cell division and up-regulates the product of the P53 gene, one of the body’s most powerful tumor-suppressor genes." ..."

Nutrition - IP6 - M. D. Anderson Cancer Center: "Precautions
IP-6 reduces platelet activity; therefore, people with low blood cell counts, or who are taking aspirin or other blood thinning medications, may want to avoid using IP-6. Because of its antioxidant properties, IP-6 may not be appropriate for patients receiving radiation or chemotherapy. Supplemental forms of IP-6 may also bind with calcium, magnesium, copper, iron and zinc and should therefore not be taken with food...
Although Dr. Shamsuddin indicates that further research must be completed before making more specific dosage recommendations, he gives the following guidelines: 1-2 g of IP-6 daily for cancer prevention, 4 g daily for people with an increased cancer risk, and up to 8 g daily for those with cancer. Patients who are considering an IP-6 supplement should consult with their physician or dietician.

IP-6 : by Ray Sahelian, M.D., inositol hexaphosphate IP-6 and cancer IP6: "Inositol hexaphosphate ( IP-6, phytic acid, or phytate ), is a naturally polyphosphorylated carbohydrate found in cereal grains, beans, brown rice, corn, sesame seeds, wheat bran, and other high fiber foods. It aids in the metabolism of insulin and calcium, hair growth, bone marrow cell metabolism, eye membrane development, and helps the liver transfer fat to other parts of the body. IP-6 in the diet may even help reduce the risk for kidney stones. Many researchers believe that some of the health benefits may be due to the antioxidant, immune enhancing, and cardiovascular supporting activities of IP-6. In-vitro and animal research has shown IP-6 to have significant protective and growth regulating effects on various cells and tissues including those of the colon, breast, and prostate...IP-6 has been reported to have in vivo and in vitro anti- cancer activity against numerous tumors, such as colon cancer, prostate cancer, breast cancer, liver cancer, chronic myeloid leukemia, pancreatic cancer, and rhabdomyosarcomas. Significant human trials are lacking and hence we do not currently know for certain whether taking IP-6 supplements are helpful in cancer prevention or therapy, but the early data look promising. "

Protection against cancer by dietary IP6 and inosi...[Nutr Cancer. 2006] - PubMed Result: "Protection against cancer by dietary IP6 and inositol."

IP6 and Inositol Product Info: FAQ "Why combine IP6 with Inositol?
Dr. Shamsuddin theorized that when Inositol was properly combined with IP-6 it formed two molecules of IP-3 in the body. Although IP-6 gets all the attention, it is really the IP-3 that is doing all the work. IP-3 plays an important role in cells by helping them grow, mature, replicate and communicate with other cells. Cells that are low in IP-3 can become out of control, dividing uncontrollably. Studies confirm that the combination of IP-6 with Inositol yields much greater effects than IP-6 alone..
IP6 plus Inositol as an Antioxidant and NK-Cell Stimulant. Recognized as a potent antioxidant, IP6 acts to neutralize the damaging effects of free radicals on body cells and has been shown to enhance immunity by boosting the activity of natural killer (NK) cells.* These immune system cells (also called lymphocytes) are the body’s first line defense mechanism. Additional research indicates IP-6 & Inositol may support healthy renal function,* promotes heart health,* and helps maintain healthy glucose metabolism.* IP6 Gold is a rich source calcium, phosphorus and magnesium that supports and maintains strong, healthy bones...Developments from laboratory data suggest IP6 and Inositol play an important role in DNA functions such as cell division, repair and maturation.* Enhancing DNA function helps maintain a healthy genetic profile. Millions of dollars are currently being spent in research related to DNA profiling and alteration. Here we see a very natural compound plays an important role in this complex mechanism.

Can IP6 plus Inositol be used alongside conventional treatments? IP6 and Inositol has undergone extensive animal and human studies. No negative side-effects have been found, either when IP6 and Inositol is used on its own or in combination with other dietary supplements or conventional allopathic treatments. Indeed, Dr. Shamsuddin states that IP6 & Inositol may actually potentiate these treatments.

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