Common Pain Drug May Cut Aspirin Lifeline in People at High Risk for Heart Disease WebMD 4/4/07 "the study provides a clear warning sign that ibuprofen is risky for people who need the blood-clot-reducing effect of daily low-dose aspirin...“Those taking aspirin in the ibuprofen arm of the study had a ninefold excess of heart attacks," Farkouh says...The whole Vioxx thing was based on 64 heart events among 21,000 patients studied," Farkouh says. "Here we are talking about potentially a higher magnitude of impact. The interaction of ibuprofen with aspirin is a bigger public health concern than Vioxx was."...Farkouh and Nissen say there is strong evidence that ibuprofen blocks the blood-clot-preventing effects of aspirin. Both agree that the drugs do not interact if a person takes aspirin two hours before taking ibuprofen..."
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