New research on insulin resistance and metabolic syndrome

Metabolic Syndrome: Don't Blame The Belly Fat ScienceDaily 7/19/07 "... insulin resistance in skeletal muscle leads to alterations in energy storage that set the stage for the metabolic syndrome...insulin resistance in skeletal muscle -- caused by decreased ability of muscle to make glycogen, the stored form of carbohydrate from food energy -- can promote an elevated pattern of lipids or fats in the bloodstream that underpins the metabolic syndrome..."Our hypothesis was that the metabolic syndrome is really a problem with how we store energy from food," Shulman explained. "The idea is that insulin resistance in muscle changes the pattern of energy storage."...Another key observation was that skeletal muscle insulin resistance precedes the development of insulin resistance in liver cells, and that fat production in the liver is increased. "These findings also have important implications for understanding the pathogenesis of nonalcoholic fatty liver disease, one of the most prevalent liver diseases in both adults and children" Shulman said... The good news, according to Shulman, is that insulin resistance in skeletal muscle can be countered through a simple intervention: exercise. "

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