Black Raspberries Slow Cancer By Altering Hundreds Of Genes

Black Raspberries Slow Cancer By Altering Hundreds Of Genes: "ScienceDaily (Aug. 27, 2008) — New research strongly suggests that a mix of preventative agents, such as those found in concentrated black raspberries, may more effectively inhibit cancer development than single agents aimed at shutting down a particular gene...Researchers at the Ohio State University Comprehensive Cancer Center examined the effect of freeze-dried black raspberries on genes altered by a chemical carcinogen in an animal model of esophageal cancer...The carcinogen affected the activity of some 2,200 genes in the animals’ esophagus in only one week, but 460 of those genes were restored to normal activity in animals that consumed freeze-dried black raspberry powder as part of their diet during the exposure...“We have clearly shown that berries, which contain a variety of anticancer compounds, have a genome-wide effect on the expression of genes involved in cancer development,”...Stoner notes that black raspberries have vitamins, minerals, phenols and phytosterols, many of which individually are known to prevent cancer in animals...“Freeze drying the berries concentrates these elements about ten times, giving us a power pack of chemoprevention agents that can influence the different signaling pathways that are deregulated in cancer,” he says...“What’s emerging from studies in cancer chemoprevention is that using single compounds alone is not enough,” Stoner says. “And berries are not enough. We never get 100 percent tumor inhibition with berries. So we need to think about another food that we can add to them that will boost the chemopreventive activities of berries alone.”..."

Another part of the equation must surely be the chemoprevention found in cruciferous vegetables - such as sulforaphanes in broccoli.

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Studies show how fruits and veggies reduce cancer

Studies show how fruits and veggies reduce cancer - Yahoo! News
2007.12.07
"Just three servings a month of raw broccoli or cabbage can reduce the risk of bladder cancer by as much as 40 percent...These foods are rich in compounds called isothiocyanates, which are known to lower cancer risk..."Cooking can reduce 60 to 90 percent of ITCs, (isothiocyanates)," Dr. Li Tang...A second team of researchers from Roswell Park tested broccoli sprouts in rats.They used rats engineered to develop bladder cancer and fed some of them a freeze-dried extract of broccoli sprouts. The more they ate, the less likely they were to develop bladder cancer, said Dr. Yuesheng Zhang"...In a third study, a team at The Ohio State University fed black raspberries to patients with Barrett's esophagus, a condition that can lead to esophageal cancer...Ohio State's Laura Kresty and colleagues fed 1.1 ounces (32 grams) of freeze-dried black raspberries to women with Barrett's esophagus and 1.6 ounces (45 grams) to men every day for six months...They measured urine levels of levels of two compounds -- 8-isoprostane and GSTpi -- that indicate whether cancer-causing processes are going on in the body...Kresty said 58 percent of patients had marked declines of 8-isoprostane levels, suggesting less damage, and 37 percent had higher levels of GSTpi, which can help interfere with cancer causing damage and which is usually low in patients with Barrett's."


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Black rasberry extract might help prevent skin cancer

Black Raspberries Yield Possible Skin Cancer Treatment ScienceDaily 4/19/07 "Researchers at the Ohio State University Medical Center say a topical compound made of black raspberries significantly slows the growth of squamous cell carcinomas of the skin in mice exposed to ultraviolet B (UVB) radiation, the most dangerous light in the solar spectrum...“In terms of shutting down the inflammatory response, we’ve never seen anything like it,” says Dr. Anne VanBuskirk...Many studies have demonstrated a link between inflammation and cancer. Normally, inflammation – the reddened area from a sunburn, for example – is tightly managed by a complex network of repair and growth factor mechanisms. VanBuskirk and others say that when these signals are mistakenly left on or shut off, perhaps as a result of DNA damage or oxidative stress, cancer can take root and grow... She says an extract of black raspberries (freeze-dried, ground up and suspended in KY jelly in their experiment) may be a good countermeasure because they contain anthacyanins, powerful antioxidants that give the fruit its rich, dark color. “In our experiments, the black raspberry treatment significantly reduced inflammatory damage and reduced tumor growth and spread.”...In the acute setting, the UVB rays produced significant edema and increased skin thickening by 67 percent in the mice treated with the gel alone. The myeloperoxidase levels rose 500 percent in that group. In the mice treated with the black raspberry gel, the scientists found that the skin thickened only 20 percent, and myeloperoxidase levels rose only 37 percent...“If repeated studies bear out these findings, it could mean that one day we may be seeing a topical gel that could be used after you get sunburned – one that not only eases pain, but also lessens any sun damage you might have already suffered.” ...“The berry extract is a natural product – it had no discernible side effects.” And not to worry about purple skin, either. VanBuskirk says the amount of raspberry extract needed for therapeutic benefit is so small it didn’t even stain the animals’ skin."

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Blueberries might help prevent colon cancer

Blueberries May Help Curb Colon Cancer Washington Post 3/27/07 "a natural compound called pterostilbene -- found in blueberries and other fruits -- helped prevent pre-cancerous colon lesions in rats..."Pterostilbene is an antioxidant and an anti-inflammatory agent that is mostly found in blueberries and blackberries," said study leader Bandaru Reddy...Colon cancer is one of the major cancers in Western countries, and this study is one of the first to show pterostilbene's potential to fight it...the rats who were fed pterostilbene had 57 percent fewer pre-cancerous lesions in their colon...Ingesting pterostilbene also reduced colonic cell proliferation and inhibited the expression of certain genes involved in inflammation -- both of these are considered to be risk factors for colon cancer...The next step is to further test pterostilbene in animals to see if it can prevent tumors. Only then will human trials be possible...Another study from Ohio State University found that rodents whose diets were supplemented with black raspberries had up to an 80 percent reduction in colon tumors and a 60 percent reduction in tumors of the esophagus...researchers in Germany were to report on a study that found drinking two to three glasses of cloudy (or unfiltered) apple juice a day may curb colon cancer in mice..."

More on blueberries and colon cancer at ScienceDaily.

Previous post on potential health benefits of pterostilbene - cousin of resveratrol.

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