Broccoli Could Reverse The Heart Damaging Effects Of Diabetes

Broccoli Could Reverse The Heart Damaging Effects Of Diabetes: "ScienceDaily (Aug. 26, 2008) — Researchers have discovered eating broccoli could undo the damage caused by diabetes to heart blood vessels...a broccoli compound called Sulforaphane. This compound can encourage the body to produce more enzymes to protect the vessels, as well as reduce high levels of molecules which cause significant cell damage...Past studies have shown that a diet rich in vegetables – particularly brassica vegetables such as broccoli – is linked to decreased risk of heart disease and stroke...The results of the study showed that Sulforaphane reversed this increase in ROS by 73 per cent...Sulforaphane activated a protein in the body called nrf2, which protects cells and tissues from oxidative stress by activating protective antioxidant and detoxifying enzymes. The study showed the presence of Sulforaphane in human microvascular cells doubled the activation of nrf2..."

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Broccoli may undo diabetes damage

BBC NEWS | Health | Broccoli may undo diabetes damage:
2008.08.05
"A University of Warwick team believe the key is a compound found in the vegetable, called sulforaphane...It encourages production of enzymes which protect the blood vessels, and a reduction in high levels of molecules which cause significant cell damage. Brassica vegetables such as broccoli have previously been linked to a lower risk of heart attacks and strokes...They recorded a 73% reduction of molecules in the body called Reactive Oxygen Species (ROS)...Hyperglycaemia can cause levels of ROS to increase three-fold and such high levels can damage human cells...The researchers also found that sulforaphane activated a protein in the body called nrf2, which protects cells and tissues from damage by activating protective antioxidant and detoxifying enzymes... "

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Flavanoids in orange Juice prove surprisingly powerful

Orange juice flavanoids fight disease? NutraIngredients.com 7/19/07 "Orange juice is a healthy drink due to the presence of flavonoids, which help fight diseases such as diabetes and heart disease...Paresh Dandona, the study's senior author, concluded that the study's findings are more important than fears over the sugar content of juice, especially in the US...We were intrigued by the fact that there was no increase in ROS or inflammation following orange juice consumption, even though its glucose concentration was the same as in participants in the glucose group," said Dandona.Further tests suggested that one of the flavonoids in orange juice, naringenin, inhibited ROS by massive 77 per cent..."

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Longevity and cytochrome b

Exceptional longevity in songbirds is associated with high rates of evolution of cytochrome b, suggesting selection for reduced generation of free radicals The Journal of Experimental Biology 6/11/07 "...contrary to expectation, in several mammalian taxa, exceptional longevity is associated with high basal metabolic rate, and also fast evolution of mtDNA-coded proteins. The association of these traits was suggested to result from adaptive selection of mutations in mtDNA-coded proteins, which accelerates basal respiration, thus inhibiting the generation of reactive oxygen species that constrain longevity. In birds, all the genera with high rate of cytochrome b evolution are songbirds (oscines)...In Serinus, a genus of finches (canaries) that exhibits the highest rate of cytochrome b evolution, and the highest values of exceptional longevity and lifetime expenditure of energy in all birds, many of the substitutions in cytochrome b are clustered around Qi, a ubiquinone binding site adjacent to the mitochondrial matrix, apparently selected to increase the rate of ubiquinone reduction. We therefore suggest that, in songbirds, the accelerated evolution of cytochrome b involved selection of mutations that reduce the generation of reactive oxygen species, thus contributing to the evolution of exceptional longevity, and possibly also exceptional long-term memory, which is necessary for learning songs..."

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