Cannabis: Potent Anti-depressant In Low Doses, Worsens Depression At High Doses

Cannabis: Potent Anti-depressant In Low Doses, Worsens Depression At High Doses - ScienceDaily
2007.10.24
"...a synthetic form of THC, the active ingredient in cannabis, is an effective anti-depressant at low doses. However, at higher doses, the effect reverses itself and can actually worsen depression and other psychiatric conditions like psychosis...this study offers the first evidence that cannabis can also increase serotonin, at least at lower doses...Laboratory animals were injected with the synthetic cannabinoid WIN55,212-2 and then tested with the Forced Swim test ...The anti-depressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids," which are released under conditions of high stress or pain, explained Dr. Gobbi. They interact with the brain through structures called cannabinoid CB1 receptors. This study demonstrates for the first time that these receptors have a direct effect on the cells producing serotonin, which is a neurotransmitter that regulates the mood..."

"DogVitals dog supplement - helping dogs live a younger, healthier life