Tuesday, January 29, 2008

Longer-lived Rodents Have Lower Levels Of Thyroid Hormone

Longer-lived Rodents Have Lower Levels Of Thyroid Hormone - ScienceDaily
2006.10.12
"The thyroid may play an important role in longevity, with longer-lived rodents showing significantly lower levels of a thyroid hormone that speeds metabolism..."Mice strains that exhibit extended longevity tend to have lower thyroid hormone concentrations than shorter living strains," the authors wrote. "Significant declines in thyroid hormone correlate well with enhanced maximum lifespan."...The study compared the levels of these thyroid hormones among four groups of rodents with different life spans: mice, guinea pigs, Damara mole-rats and naked mole-rats. Mice live to about three and a half years; guinea pigs live to six years; Damara mole-rats to 15 years; and naked mole-rats to 28 years...T4 levels varied significantly between all of the groups, with the shorter-lived groups having higher levels of T4 than longer-lived groups. The mice, for example, had twice as much T4 as the Damara mole-rats and had and three times more than that of the naked mole-rats, Pinto reported. There was also a significant difference in T3 levels between the naked mole-rats and the guinea pigs, but not between any of the other groups..."

An old article, but worth revisiting.

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