Fatigue relief drug's heart hope BBC News
2008.02.12
"...A Columbia University team found fatigue following exercise is caused by calcium leaking inside muscle cells. They formulated a drug to plug the leaks, and successfully used it to relieve fatigue in exhausted mice...They also believe that calcium leaks are responsible for severe exhaustion in heart failure patients...It had previously been thought that fatigue following intense, sustained exercise such as marathon running was due to the accumulation of lactic acid in the muscles...The latest research pinpoints a tiny leak inside the muscle cells as the culprit. The leak - which allows calcium to seep continuously inside the muscle cells - weakens the force produced by the muscle and also turns on a protein-digesting enzyme that damages the muscle fibres. The researchers found the leak was present in the muscle of mice after an intense three-week daily regime of swimming, and in human athletes after three days of intense cycling. The Columbia team had previously identified the same leak in the muscles of animals with heart failure...The researchers gave their experimental drug to mice before the animals started a three-week regime of swimming. Without the drugs the animals were exhausted after three weeks, but those that received the drug were still energetic at the end of the exercise programme, and their muscles showed less signs of damage... "
More research is needed, but this might be amazing for some heart disease patients. And could be amusing to see endurance athletes claiming after busted for the improper use of this drug... that they were using it for heart disease.
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Monday, February 11, 2008
Wednesday, February 6, 2008
'Weight Training' Reduces Fat And Improve Metabolism In Mice
'Weight Training' Reduces Fat And Improve Metabolism In Mice ScienceDaily
2008.02.05
"... the use of barbells may be as important to losing weight and improving health as the use of running shoes...The discovery builds upon the fact that skeletal muscle consists of two types of fibers. Endurance training such as running increases the amount of type I muscle fibers, while resistance training such as weightlifting increases type II muscle fibers. Using a mouse genetic model, BUSM researchers demonstrated that an increase in type II muscle mass can reduce body fat which in turn reduces overall body mass and improves metabolic parameters such as insulin resistance..."Beyond the age of thirty, humans lose approximately 6 lbs of muscle mass per decade. Surprisingly, aging individuals predominantly lose type II muscle."...the beneficial effects of muscle growth seen in the MyoMouse are mediated through the production and secretion of a variety of signaling factors...These new proteins, referred to as "myokines" from the Greek words "muscle" and "motion,"..."
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.02.05
"... the use of barbells may be as important to losing weight and improving health as the use of running shoes...The discovery builds upon the fact that skeletal muscle consists of two types of fibers. Endurance training such as running increases the amount of type I muscle fibers, while resistance training such as weightlifting increases type II muscle fibers. Using a mouse genetic model, BUSM researchers demonstrated that an increase in type II muscle mass can reduce body fat which in turn reduces overall body mass and improves metabolic parameters such as insulin resistance..."Beyond the age of thirty, humans lose approximately 6 lbs of muscle mass per decade. Surprisingly, aging individuals predominantly lose type II muscle."...the beneficial effects of muscle growth seen in the MyoMouse are mediated through the production and secretion of a variety of signaling factors...These new proteins, referred to as "myokines" from the Greek words "muscle" and "motion,"..."
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Daily Glass Of Beet Juice Can Beat High Blood Pressure
Daily Glass Of Beet Juice Can Beat High Blood Pressure, Study Shows ScienceDaily
2008.02.06
"...drinking just 500ml of beetroot juice a day can significantly reduce blood pressure. The study could have major implications for the treatment of cardiovascular disease... it is the ingestion of dietary nitrate contained within beetroot juice - and similarly in green, leafy vegetables - which results ultimately in decreased blood pressure...blood pressure was reduced within just 1 hour of ingesting beetroot juice, with a peak drop occurring 3-4 hours after ingestion. Some degree of reduction continued to be observed until up to 24 hours after ingestion...The nitrate in the juice is converted in saliva, by bacteria on the tongue, into nitrite. This nitrite-containing saliva is swallowed, and in the acidic environment of the stomach is either converted into nitric oxide or re-enters the circulation as nitrite. The peak time of reduction in blood pressure correlated with the appearance and peak levels of nitrite in the circulation..."
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.02.06
"...drinking just 500ml of beetroot juice a day can significantly reduce blood pressure. The study could have major implications for the treatment of cardiovascular disease... it is the ingestion of dietary nitrate contained within beetroot juice - and similarly in green, leafy vegetables - which results ultimately in decreased blood pressure...blood pressure was reduced within just 1 hour of ingesting beetroot juice, with a peak drop occurring 3-4 hours after ingestion. Some degree of reduction continued to be observed until up to 24 hours after ingestion...The nitrate in the juice is converted in saliva, by bacteria on the tongue, into nitrite. This nitrite-containing saliva is swallowed, and in the acidic environment of the stomach is either converted into nitric oxide or re-enters the circulation as nitrite. The peak time of reduction in blood pressure correlated with the appearance and peak levels of nitrite in the circulation..."
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Monday, February 4, 2008
Low folate linked to dementia
Low folate levels associated with dementia BBC News
2008.02.05
"Dementia is three times more common in people whose blood is low in folates, a form of vitamin B particularly found in green vegetables...There is growing evidence linking levels of folates - or folic acid - and Alzheimer's disease, though deficiency could be a symptom of dementia..."
But remember folic acid has now been associated with cancer so get the natural form, folate, through green leafies.
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.02.05
"Dementia is three times more common in people whose blood is low in folates, a form of vitamin B particularly found in green vegetables...There is growing evidence linking levels of folates - or folic acid - and Alzheimer's disease, though deficiency could be a symptom of dementia..."
But remember folic acid has now been associated with cancer so get the natural form, folate, through green leafies.
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Babies absorb phthalates from baby products
Babies absorb phthalates from baby products Yahoo! News
2008.02.04
"A new study suggests that baby lotion, baby powder, and baby shampoo may be exposing babies to potentially harmful chemicals called phthalates..."At this time, we do not know what the potential long-term health effects might be, but there is a large body of animal studies to suggest developmental and reproductive toxicity (from phthalates) and a few human studies with changes in health outcomes as well," Dr. Sheela Sathyanarayana"...Phthalates are used to make plastics flexible and stabilize fragrances, and are found in a plethora of consumer products including toys, personal care products and medical equipment...All of the urine samples contained at least one phthalate at measurable levels, they report, and 81 percent of the samples had measurable amounts of seven or more phthalates...""We found that reported use of baby lotion, baby shampoo, and baby powder was associated with increased concentrations of monethyl phthalate (MEP), monomethyl phthalate (MMP), and monoisobutyl phthalate (MIBP) in infant urine,"...This association was strongest in young infants less than 8 months old, "who may be more vulnerable to developmental and reproductive toxicity of phthalates...At present, U.S. manufacturers are not required to list phthalate contents on products' package labels, making it hard for parents to make informed decisions..."If parents want to decrease exposures for their children, they can try to use lotions, shampoo, and baby powder sparingly unless otherwise indicated for a medical reason," "
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.02.04
"A new study suggests that baby lotion, baby powder, and baby shampoo may be exposing babies to potentially harmful chemicals called phthalates..."At this time, we do not know what the potential long-term health effects might be, but there is a large body of animal studies to suggest developmental and reproductive toxicity (from phthalates) and a few human studies with changes in health outcomes as well," Dr. Sheela Sathyanarayana"...Phthalates are used to make plastics flexible and stabilize fragrances, and are found in a plethora of consumer products including toys, personal care products and medical equipment...All of the urine samples contained at least one phthalate at measurable levels, they report, and 81 percent of the samples had measurable amounts of seven or more phthalates...""We found that reported use of baby lotion, baby shampoo, and baby powder was associated with increased concentrations of monethyl phthalate (MEP), monomethyl phthalate (MMP), and monoisobutyl phthalate (MIBP) in infant urine,"...This association was strongest in young infants less than 8 months old, "who may be more vulnerable to developmental and reproductive toxicity of phthalates...At present, U.S. manufacturers are not required to list phthalate contents on products' package labels, making it hard for parents to make informed decisions..."If parents want to decrease exposures for their children, they can try to use lotions, shampoo, and baby powder sparingly unless otherwise indicated for a medical reason," "
DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Tuesday, January 29, 2008
Sedentary Lifestyles Associated With Accelerated Aging Process
Sedentary Lifestyles Associated With Accelerated Aging Process - ScienceDaily
2008.01.29
"Individuals who are physically active during their leisure time appear to be biologically younger than those with sedentary lifestyles...Regular exercisers have lower rates of cardiovascular disease, type 2 diabetes, cancer, high blood pressure, obesity and osteoporosis, according to background information in the article. "A sedentary lifestyle increases the propensity to aging-related disease and premature death," the authors write. "Inactivity may diminish life expectancy not only by predisposing to aging-related diseases but also because it may influence the aging process itself."...Telomere length decreased with age, with an average loss of 21 nucleotides (structural units) per year. Men and women who were less physically active in their leisure time had shorter leukocyte telomeres than those who were more active. "Such a relationship between leukocyte telomere length and physical activity level remained significant after adjustment for body mass index, smoking, socioeconomic status and physical activity at work," the authors write. "The mean difference in leukocyte telomere length between the most active [who performed an average of 199 minutes of physical activity per week] and least active [16 minutes of physical activity per week] subjects was 200 nucleotides, which means that the most active subjects had telomeres the same length as sedentary individuals up to 10 years younger, on average." A sub-analysis comparing pairs in which twins had different levels of physical activity showed similar results...Oxidative stress--damage caused to cells by exposure to oxygen--and inflammation are likely mechanisms by which sedentary lifestyles shorten telomeres, the authors suggest. In addition, perceived stress levels have been linked to telomere length. Physical activity may reduce psychological stress, thus mitigating its effect on telomeres and the aging process..."
Rounding 3rd and heading for home in this batch of research showing that exercise not only makes you healthier it'll probably make you live longer and vice versa for lethargy.
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2008.01.29
"Individuals who are physically active during their leisure time appear to be biologically younger than those with sedentary lifestyles...Regular exercisers have lower rates of cardiovascular disease, type 2 diabetes, cancer, high blood pressure, obesity and osteoporosis, according to background information in the article. "A sedentary lifestyle increases the propensity to aging-related disease and premature death," the authors write. "Inactivity may diminish life expectancy not only by predisposing to aging-related diseases but also because it may influence the aging process itself."...Telomere length decreased with age, with an average loss of 21 nucleotides (structural units) per year. Men and women who were less physically active in their leisure time had shorter leukocyte telomeres than those who were more active. "Such a relationship between leukocyte telomere length and physical activity level remained significant after adjustment for body mass index, smoking, socioeconomic status and physical activity at work," the authors write. "The mean difference in leukocyte telomere length between the most active [who performed an average of 199 minutes of physical activity per week] and least active [16 minutes of physical activity per week] subjects was 200 nucleotides, which means that the most active subjects had telomeres the same length as sedentary individuals up to 10 years younger, on average." A sub-analysis comparing pairs in which twins had different levels of physical activity showed similar results...Oxidative stress--damage caused to cells by exposure to oxygen--and inflammation are likely mechanisms by which sedentary lifestyles shorten telomeres, the authors suggest. In addition, perceived stress levels have been linked to telomere length. Physical activity may reduce psychological stress, thus mitigating its effect on telomeres and the aging process..."
Rounding 3rd and heading for home in this batch of research showing that exercise not only makes you healthier it'll probably make you live longer and vice versa for lethargy.
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From And For The Heart, My Dear Valentine: Broccoli
From And For The Heart, My Dear Valentine: Broccoli - ScienceDaily
2008.01.24
"...Das and colleagues now report evidence on that topic from animal studies. They gave broccoli extract to lab rats for one month and measured its effects on the rats' heart muscle. Compared to a control group that ate a regular diet, the broccoli-fed animals had improved heart function and less heart muscle damage when deprived of oxygen. Broccoli's heart-healthy effects are likely due to its high concentrations of certain substances that seem to boost levels of a heart-protective protein called thioredoxin, the researchers note.
2008.01.24
"...Das and colleagues now report evidence on that topic from animal studies. They gave broccoli extract to lab rats for one month and measured its effects on the rats' heart muscle. Compared to a control group that ate a regular diet, the broccoli-fed animals had improved heart function and less heart muscle damage when deprived of oxygen. Broccoli's heart-healthy effects are likely due to its high concentrations of certain substances that seem to boost levels of a heart-protective protein called thioredoxin, the researchers note.
The article "Broccoli: A Unique Vegetable That Protects Mammalian Hearts through the Redox Cycling of the Thioredoxin Superfamily" is scheduled for the Jan. 23 issue of ACS' Journal of Agricultural and Food Chemistry."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier lifeDaily Exercise Dramatically Lowers Men's Death Rates
Daily Exercise Dramatically Lowers Men's Death Rates - ScienceDaily
2008.01.23
"...The government-supported Veterans Affairs study included 15,660 participants and is the largest known to assess the link between fitness and mortality..."It is important to emphasize that it takes relatively moderate levels of physical activity -- like brisk walking -- to attain the associated health benefits. Certainly, one does not need to be a marathon runner...The study found that "highly fit" men had half the risk of death compared to "low fit" men. Men who achieved "very highly fit" levels had a 70 percent lower risk of death compared to those in the "low fit" category. For every 1-MET increase in exercise capacity (fitness), the risk for death from all causes was 13 percent for both African Americans and Caucasians..."Our findings show that the risk of death is cut in half with an exercise capacity that can easily be achieved by a brisk walk of about 30 minutes per session 5-6 days per week," he added. "Physicians should encourage individuals to initiate and maintain a physically active lifestyle, which is likely to improve fitness and lower the risk of death...."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.01.23
"...The government-supported Veterans Affairs study included 15,660 participants and is the largest known to assess the link between fitness and mortality..."It is important to emphasize that it takes relatively moderate levels of physical activity -- like brisk walking -- to attain the associated health benefits. Certainly, one does not need to be a marathon runner...The study found that "highly fit" men had half the risk of death compared to "low fit" men. Men who achieved "very highly fit" levels had a 70 percent lower risk of death compared to those in the "low fit" category. For every 1-MET increase in exercise capacity (fitness), the risk for death from all causes was 13 percent for both African Americans and Caucasians..."Our findings show that the risk of death is cut in half with an exercise capacity that can easily be achieved by a brisk walk of about 30 minutes per session 5-6 days per week," he added. "Physicians should encourage individuals to initiate and maintain a physically active lifestyle, which is likely to improve fitness and lower the risk of death...."
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Moderate Exercise Yields Big Benefits
Moderate Exercise Yields Big Benefits - ScienceDaily
2008.01.04
"...The January issue of Mayo Clinic Health Letter lists some of the benefits of 30 minutes of exercise a day:
2008.01.04
"...The January issue of Mayo Clinic Health Letter lists some of the benefits of 30 minutes of exercise a day:
- Lower blood pressure: A reduction of 5 to 10 millimeters of mercury (mm Hg) is possible. In some cases, that’s enough to prevent or reduce the need for blood pressure medications.
- Improve cholesterol: Exercise often increases the concentration of high-density lipoprotein (HDL or “good” cholesterol in the blood), especially when accompanied by weight loss. Exercise also helps reduce triglyceride levels.
- Prevent or manage type 2 diabetes: Exercise helps insulin work better, lowering blood sugar.
- Manage weight: Coupling exercise with a healthy diet is the best way to shed fat and maintain a healthier body composition.
- Prevent osteoporosis: Exercise may increase bone density and protect against bone mass decline, especially if weight-bearing activities are involved.
- Prevent cancer: Exercise has been shown to strengthen the immune system, improve circulation, reduce body fat and speed digestion. Each has a role in preventing cancer, particularly cancers of the colon, prostate, uterine lining and breast.
- Maintain mental well-being: Exercise may help reduce stress, improve mild-to-moderate depression and anxiety, improve sleep and boost moods.
- Increase energy and stamina: A lack of energy often results from inactivity, not age.""
Longer-lived Rodents Have Lower Levels Of Thyroid Hormone
Longer-lived Rodents Have Lower Levels Of Thyroid Hormone - ScienceDaily
2006.10.12
"The thyroid may play an important role in longevity, with longer-lived rodents showing significantly lower levels of a thyroid hormone that speeds metabolism..."Mice strains that exhibit extended longevity tend to have lower thyroid hormone concentrations than shorter living strains," the authors wrote. "Significant declines in thyroid hormone correlate well with enhanced maximum lifespan."...The study compared the levels of these thyroid hormones among four groups of rodents with different life spans: mice, guinea pigs, Damara mole-rats and naked mole-rats. Mice live to about three and a half years; guinea pigs live to six years; Damara mole-rats to 15 years; and naked mole-rats to 28 years...T4 levels varied significantly between all of the groups, with the shorter-lived groups having higher levels of T4 than longer-lived groups. The mice, for example, had twice as much T4 as the Damara mole-rats and had and three times more than that of the naked mole-rats, Pinto reported. There was also a significant difference in T3 levels between the naked mole-rats and the guinea pigs, but not between any of the other groups..."
An old article, but worth revisiting.
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2006.10.12
"The thyroid may play an important role in longevity, with longer-lived rodents showing significantly lower levels of a thyroid hormone that speeds metabolism..."Mice strains that exhibit extended longevity tend to have lower thyroid hormone concentrations than shorter living strains," the authors wrote. "Significant declines in thyroid hormone correlate well with enhanced maximum lifespan."...The study compared the levels of these thyroid hormones among four groups of rodents with different life spans: mice, guinea pigs, Damara mole-rats and naked mole-rats. Mice live to about three and a half years; guinea pigs live to six years; Damara mole-rats to 15 years; and naked mole-rats to 28 years...T4 levels varied significantly between all of the groups, with the shorter-lived groups having higher levels of T4 than longer-lived groups. The mice, for example, had twice as much T4 as the Damara mole-rats and had and three times more than that of the naked mole-rats, Pinto reported. There was also a significant difference in T3 levels between the naked mole-rats and the guinea pigs, but not between any of the other groups..."
An old article, but worth revisiting.
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Scientists discover way to reverse memory loss
Scientists discover way to reverse loss of memory - Science, News - Independent.co.uk
2008.01.30
"...The accidental breakthrough came during an experiment originally intended to suppress the obese man's appetite, using the increasingly successful technique of deep-brain stimulation. Electrodes were pushed into the man's brain and stimulated with an electric current. Instead of losing appetite, the patient instead had an intense experience of déjà vu. He recalled, in intricate detail, a scene from 30 years earlier. More tests showed his ability to learn was dramatically improved when the current was switched on and his brain stimulated...Professor Lozano said: "This is the first time that anyone has had electrodes implanted in the brain which have been shown to improve memory. We are driving the activity of the brain by increasing its sensitivity – turning up the volume of the memory circuits. Any event that involves the memory circuits is more likely to be stored and retained."...Speaking to The Independent yesterday, Professor Lozano said: "His performance improved dramatically. As we turned the current up, we first drove his memory circuits and improved his learning. As we increased the intensity of the current, we got spontaneous memories of discrete events. At a certain intensity, he would slash to the scene [in the park]. When the intensity was increased further, he got more detail but, when the current was turned off, it rapidly decayed."...The discovery surprised the scientists as the hypothalamus has not usually been identified as a seat of memory. The contacts that most readily produced the memories were located close to a structure called the fornix, an arched bundle of fibres that carries signals within the limbic system, which is involved in memory and emotions and is situated next to the hypothalamus..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.01.30
"...The accidental breakthrough came during an experiment originally intended to suppress the obese man's appetite, using the increasingly successful technique of deep-brain stimulation. Electrodes were pushed into the man's brain and stimulated with an electric current. Instead of losing appetite, the patient instead had an intense experience of déjà vu. He recalled, in intricate detail, a scene from 30 years earlier. More tests showed his ability to learn was dramatically improved when the current was switched on and his brain stimulated...Professor Lozano said: "This is the first time that anyone has had electrodes implanted in the brain which have been shown to improve memory. We are driving the activity of the brain by increasing its sensitivity – turning up the volume of the memory circuits. Any event that involves the memory circuits is more likely to be stored and retained."...Speaking to The Independent yesterday, Professor Lozano said: "His performance improved dramatically. As we turned the current up, we first drove his memory circuits and improved his learning. As we increased the intensity of the current, we got spontaneous memories of discrete events. At a certain intensity, he would slash to the scene [in the park]. When the intensity was increased further, he got more detail but, when the current was turned off, it rapidly decayed."...The discovery surprised the scientists as the hypothalamus has not usually been identified as a seat of memory. The contacts that most readily produced the memories were located close to a structure called the fornix, an arched bundle of fibres that carries signals within the limbic system, which is involved in memory and emotions and is situated next to the hypothalamus..."
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Thursday, January 24, 2008
Folic Acid Supplementation Associated With Reduced Risk Of Preeclampsia During Pregnancy
Large Study Links Folic Acid Supplementation With Reduced Risk Of Preeclampsia During Pregnancy - ScienceDaily
2008.01.24
"...preeclampsia occurred in 2.2 per cent of women who took multivitamins containing folic acid compared to 5.1 per cent of women who did not...Society of Obstetricians and Gynaecologists of Canada recommends a dose of 1 mg per day. In the current study, 92 per cent of women were taking folic acid, mostly at the higher dose..."
Low Vitamin D During Pregnancy Linked To Pre-eclampsia
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2008.01.24
"...preeclampsia occurred in 2.2 per cent of women who took multivitamins containing folic acid compared to 5.1 per cent of women who did not...Society of Obstetricians and Gynaecologists of Canada recommends a dose of 1 mg per day. In the current study, 92 per cent of women were taking folic acid, mostly at the higher dose..."
Low Vitamin D During Pregnancy Linked To Pre-eclampsia
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Study Links Caffeine to Miscarriage
Study Links Caffeine to Miscarriage WebMD
2008.01.22
"...Women in the study who consumed more than 200 mg of caffeine a day -- the amount found in about two 8-ounce cups of regular-strength coffee -- had twice the risk of miscarriage as pregnant women who consumed no caffeine...."
Reuters via Scientific American
"This risk appeared to be related to the caffeine, rather than other chemicals in coffee, because they also saw an increased risk when the caffeine was consumed in soda, tea, and hot chocolate.
"...Pregnant women should try to give up caffeine for at least the first three or four months, said the lead author of the study, Dr. De-Kun Li..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.01.22
"...Women in the study who consumed more than 200 mg of caffeine a day -- the amount found in about two 8-ounce cups of regular-strength coffee -- had twice the risk of miscarriage as pregnant women who consumed no caffeine...."
Reuters via Scientific American
"This risk appeared to be related to the caffeine, rather than other chemicals in coffee, because they also saw an increased risk when the caffeine was consumed in soda, tea, and hot chocolate.
Li said many researchers think caffeine is harmful because it stresses the fetus' immature metabolism. It may also decrease blood flow in the placenta, which could harm the fetus.
"To me, the safe dose is zero," Li said. "If you really have to drink coffee, try to limit it to one cup or at the most two cups." Or better yet, switch to decaffeinated beverages, he added."
NewYork Times"...Pregnant women should try to give up caffeine for at least the first three or four months, said the lead author of the study, Dr. De-Kun Li..."
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Thursday, January 10, 2008
Fruit, Vegetable Eaters Have Fewer Strokes
Fruit, Vegetable Eaters Have Fewer Strokes - WebMD
2008.01.09
"...University of Cambridge researchers measured vitamin C levels in more than 20,000 people, who were then followed for roughly a decade. Blood vitamin C levels tend to be much higher in people who eat lots of fruits and vegetables than in people who do not. When the participants were divided into four groups based on vitamin C levels, those with the highest concentrations of the vitamin in their blood were found to have a 42% lower stroke risk than those with the lowest concentrations...The findings do not prove that it is the vitamin C in fruits and vegetables that is protective, the researchers note.And most studies have found that taking vitamin C and other antioxidant vitamin supplements is of no benefit for lowering stroke risk..."We don't know what it is, but the message to the public is clear," he tells WebMD. "Eat a wide variety of fruits and vegetables. Think about color, and eat a rainbow of plant foods."..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.01.09
"...University of Cambridge researchers measured vitamin C levels in more than 20,000 people, who were then followed for roughly a decade. Blood vitamin C levels tend to be much higher in people who eat lots of fruits and vegetables than in people who do not. When the participants were divided into four groups based on vitamin C levels, those with the highest concentrations of the vitamin in their blood were found to have a 42% lower stroke risk than those with the lowest concentrations...The findings do not prove that it is the vitamin C in fruits and vegetables that is protective, the researchers note.And most studies have found that taking vitamin C and other antioxidant vitamin supplements is of no benefit for lowering stroke risk..."We don't know what it is, but the message to the public is clear," he tells WebMD. "Eat a wide variety of fruits and vegetables. Think about color, and eat a rainbow of plant foods."..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Four Health Behaviors Can Add 14 Extra Years Of Life
Four Health Behaviors Can Add 14 Extra Years Of Life - ScienceDaily
Via QualityCounts
2008.01.09
"People who adopt four healthy behaviours -- not smoking; taking exercise; moderate alcohol intake; and eating five servings of fruit and vegetables a day -- live on average an additional fourteen years of life compared with people who adopt none of these behaviours...Kay-Tee Khaw and colleagues from the University of Cambridge and the Medical Research Council used a health behaviour score that is easy to understand in order to assess the participants in the study (who were from Norfolk, United Kingdom). Between 1993 and 1997, 20,000 men and women between the ages of 45 and 79, none of whom had known cancer or heart or circulatory disease, completed a questionnaire that resulted in a score between 0 and 4...A point was awarded for each of the following: not currently smoking; not being physically inactive (physical inactivity was defined as having a sedentary job and not doing any recreational exercise); a moderate alcohol intake of 1-14 units a week (a unit is half a pint of beer or a glass of wine); and a blood vitamin C level consistent with eating five servings of fruit or vegetables a day. Deaths among the participants were recorded unti l 2006...After factoring in age, the results showed that over an average period of eleven years people with a score of 0 -- i.e. those who did not undertake any of these healthy forms of behaviour -- were four times more likely to have died than those who had scored 4 in the questionnaire."
PLoS Study link
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Via QualityCounts
2008.01.09
"People who adopt four healthy behaviours -- not smoking; taking exercise; moderate alcohol intake; and eating five servings of fruit and vegetables a day -- live on average an additional fourteen years of life compared with people who adopt none of these behaviours...Kay-Tee Khaw and colleagues from the University of Cambridge and the Medical Research Council used a health behaviour score that is easy to understand in order to assess the participants in the study (who were from Norfolk, United Kingdom). Between 1993 and 1997, 20,000 men and women between the ages of 45 and 79, none of whom had known cancer or heart or circulatory disease, completed a questionnaire that resulted in a score between 0 and 4...A point was awarded for each of the following: not currently smoking; not being physically inactive (physical inactivity was defined as having a sedentary job and not doing any recreational exercise); a moderate alcohol intake of 1-14 units a week (a unit is half a pint of beer or a glass of wine); and a blood vitamin C level consistent with eating five servings of fruit or vegetables a day. Deaths among the participants were recorded unti l 2006...After factoring in age, the results showed that over an average period of eleven years people with a score of 0 -- i.e. those who did not undertake any of these healthy forms of behaviour -- were four times more likely to have died than those who had scored 4 in the questionnaire."
PLoS Study link
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Wednesday, January 9, 2008
Fish Oil Prevents Alzheimer's Plaques
Fish Oil Prevents Alzheimer's Plaques - WebMD
Via QualityCounts
2007.12.26
"Why does fish oil help prevent Alzheimer's disease? Your brain needs a fish oil fatty acid to make a plaque-fighting protein, UCLA researchers find...It's known that people who get plenty of DHA, a fish oil fatty acid, have a reduced risk of Alzheimer's disease, note Greg M. Cole, PhD...Why? Cole's team had a clue. People with Alzheimer's disease tend to have low levels of a brain protein called LR11 (also known as SorLA). And about 15% of people with Alzheimer's disease carry a genetic mutation that reduces LR11...LR11 helps clear the brain of amyloid precursor protein, essential for production of the brain-gumming beta-amyloid plaque that clogs the brains of people with Alzheimer's disease...Sure enough, in live rodents and in cultures of human brain cells, the researchers found that the fish-oil compound DHA causes brain cells to make lots more LR11...it may be a great help if taken at the first signs of Alzheimer's"
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Via QualityCounts
2007.12.26
"Why does fish oil help prevent Alzheimer's disease? Your brain needs a fish oil fatty acid to make a plaque-fighting protein, UCLA researchers find...It's known that people who get plenty of DHA, a fish oil fatty acid, have a reduced risk of Alzheimer's disease, note Greg M. Cole, PhD...Why? Cole's team had a clue. People with Alzheimer's disease tend to have low levels of a brain protein called LR11 (also known as SorLA). And about 15% of people with Alzheimer's disease carry a genetic mutation that reduces LR11...LR11 helps clear the brain of amyloid precursor protein, essential for production of the brain-gumming beta-amyloid plaque that clogs the brains of people with Alzheimer's disease...Sure enough, in live rodents and in cultures of human brain cells, the researchers found that the fish-oil compound DHA causes brain cells to make lots more LR11...it may be a great help if taken at the first signs of Alzheimer's"
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Exercise and alcohol fights heart disease
A few drinks a day and exercise limit heart disease Reuters/YahooNews
2008.01.09
"...People who neither drink nor exercise have a 30 to 49 percent higher risk of heart disease than people who do one or both of the activities, the researchers said in the European Heart Journal...The main finding is there seems to be an additional beneficial effect of drinking one to two drinks per day and doing at least moderate physical activity...Several major studies have found that light to moderate drinking -- up to two drinks a day on a regular basis -- is associated with a lower risk of heart disease, and some have also found this leads to a lower risk of some cancers...teetotallers who exercised at least moderately were able to reduce their risk of heart disease, an important finding for people who abstain because of religious beliefs or other health issues such as pregnancy, the researchers said. People who had the lowest risk of dying from any cause were physically active, moderate drinkers while those at highest risk were the physically inactive, heavy drinkers, the study found..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2008.01.09
"...People who neither drink nor exercise have a 30 to 49 percent higher risk of heart disease than people who do one or both of the activities, the researchers said in the European Heart Journal...The main finding is there seems to be an additional beneficial effect of drinking one to two drinks per day and doing at least moderate physical activity...Several major studies have found that light to moderate drinking -- up to two drinks a day on a regular basis -- is associated with a lower risk of heart disease, and some have also found this leads to a lower risk of some cancers...teetotallers who exercised at least moderately were able to reduce their risk of heart disease, an important finding for people who abstain because of religious beliefs or other health issues such as pregnancy, the researchers said. People who had the lowest risk of dying from any cause were physically active, moderate drinkers while those at highest risk were the physically inactive, heavy drinkers, the study found..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Tuesday, December 18, 2007
High Meat Consumption Linked to Heightened Cancer Risk
High Meat Consumption Linked to Heightened Cancer Risk on Yahoo! Health
2007.12.11
"... "This is the largest study to look at the effect of red and processed meat on multiple cancer sites, including rarer cancers, such as laryngeal and liver cancer."...For the study, red meats included beef, pork and lamb. Processed meats included bacon, red-meat sausage, poultry sausage, luncheon meats, cold cuts, ham, regular hot dogs and low-fat hot dogs...elevated risks for colorectal and lung cancer with high consumption of both meat types along with borderline higher risks for advanced prostate cancer. High red meat intake was also associated with increased risk of esophageal and liver and a borderline increased risk for laryngeal cancer. And high processed meat consumption also was associated with borderline increased risk for bladder cancer and myeloma, a kind of bone cancer. In addition, both red meat and processed meat consumption were associated with increased pancreatic cancer risk in men, but not women...Meats are a source of saturated fat and iron, both of which have been linked to cancer, and also the source of several compounds that are known to affect cell development, they added...Cooking at high temperatures might also contribute to cancer risk, Cross added."Heterocyclic amines and polycyclic aromatic hydrocarbons are formed when meats are cooked well-done by high temperature cooking methods, such as barbecuing,"..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.11
"... "This is the largest study to look at the effect of red and processed meat on multiple cancer sites, including rarer cancers, such as laryngeal and liver cancer."...For the study, red meats included beef, pork and lamb. Processed meats included bacon, red-meat sausage, poultry sausage, luncheon meats, cold cuts, ham, regular hot dogs and low-fat hot dogs...elevated risks for colorectal and lung cancer with high consumption of both meat types along with borderline higher risks for advanced prostate cancer. High red meat intake was also associated with increased risk of esophageal and liver and a borderline increased risk for laryngeal cancer. And high processed meat consumption also was associated with borderline increased risk for bladder cancer and myeloma, a kind of bone cancer. In addition, both red meat and processed meat consumption were associated with increased pancreatic cancer risk in men, but not women...Meats are a source of saturated fat and iron, both of which have been linked to cancer, and also the source of several compounds that are known to affect cell development, they added...Cooking at high temperatures might also contribute to cancer risk, Cross added."Heterocyclic amines and polycyclic aromatic hydrocarbons are formed when meats are cooked well-done by high temperature cooking methods, such as barbecuing,"..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Lung cancer 'link to lack of sun'
Lung Cancer linked to lack of sun - BBC News
2007.12.18
"...Researchers found lung cancer rates were highest in countries furthest from the equator, where exposure to sunlight is lowest...It is thought vitamin D - generated by exposure to sunlight - can halt tumour growth by promoting the factors responsible for cell death in the body...vitamin D stimulated the release of chemicals which, in combination with calcium, formed a glue-like substance which bind these cells tightly together, and put a brake on their division...There was also evidence that vitamin D may also slow the progress of cancer once it develops..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.18
"...Researchers found lung cancer rates were highest in countries furthest from the equator, where exposure to sunlight is lowest...It is thought vitamin D - generated by exposure to sunlight - can halt tumour growth by promoting the factors responsible for cell death in the body...vitamin D stimulated the release of chemicals which, in combination with calcium, formed a glue-like substance which bind these cells tightly together, and put a brake on their division...There was also evidence that vitamin D may also slow the progress of cancer once it develops..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Monday, December 17, 2007
Walking packs huge health punch
Walking packs a huge health punch - Yahoo! Health
2007.12.17
"...Before exercising regularly, 41 percent of the study subjects met the criteria for metabolic syndrome. At the end of the 8-month exercise program, only 27 percent did...People in the study who exercised the least - walking 30 minutes 6 days a week or the equivalent of about 11 miles per week -- gained significant benefit, while those who exercised the most, jogging about 17 miles per week, gained slightly more benefit in terms of lowered metabolic syndrome scores...People who did a short period of very vigorous exercise didn't improve their metabolic syndrome scores as much as those who performed less intense exercise for a longer period, the researchers found...This suggests, they say, that there's more value in doing moderate intensity exercise every day rather than more intense activity just a few days a week..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.17
"...Before exercising regularly, 41 percent of the study subjects met the criteria for metabolic syndrome. At the end of the 8-month exercise program, only 27 percent did...People in the study who exercised the least - walking 30 minutes 6 days a week or the equivalent of about 11 miles per week -- gained significant benefit, while those who exercised the most, jogging about 17 miles per week, gained slightly more benefit in terms of lowered metabolic syndrome scores...People who did a short period of very vigorous exercise didn't improve their metabolic syndrome scores as much as those who performed less intense exercise for a longer period, the researchers found...This suggests, they say, that there's more value in doing moderate intensity exercise every day rather than more intense activity just a few days a week..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Friday, December 14, 2007
Aging Gracefully Requires Taking Out The Trash
Aging Gracefully Requires Taking Out The Trash - ScienceDaily
2007.12.14
"Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration...Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity..."suggests there is an age-dependent suppression of autophagy that may be a contributing factor for human neurodegenerative disorders like Alzheimer's disease"...The age-related accumulation of proteins and lipids damaged by chemically aggressive forms of oxygen is considered by most in the geriatrics field to be a normal part of the aging process. As a result in most age-associated diseases, such as Alzheimer's, damaged proteins accumulate in excessive amounts, which leads to progressive cell death in the brain...When the researchers kept the neuronal levels of Atg8a high, the genetically engineered flies were spared the ravages of time. Promoting the pathway not only prevented the accumulation of protein aggregates but also significantly extended the average lifespan. "Our experiments show for the first time genetically that autophagy can sequester and eliminate misfolded and damaged proteins, which accumulate in neurons as normal part of the aging process," says Simonsen...Insulin signaling and caloric restriction are two major determinants of longevity and they also impact the activity level of autophagy. Therefore, regulating autophagy, the pathway that directly does the cleanup work, may be the key factor in controlling the aging process..."By maintaining the expression of a rate-limiting autophagy gene in the aging nervous system there is a dramatic extension of lifespan and resistance to age-associated oxidative stress," says Finley."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.14
"Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration...Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity..."suggests there is an age-dependent suppression of autophagy that may be a contributing factor for human neurodegenerative disorders like Alzheimer's disease"...The age-related accumulation of proteins and lipids damaged by chemically aggressive forms of oxygen is considered by most in the geriatrics field to be a normal part of the aging process. As a result in most age-associated diseases, such as Alzheimer's, damaged proteins accumulate in excessive amounts, which leads to progressive cell death in the brain...When the researchers kept the neuronal levels of Atg8a high, the genetically engineered flies were spared the ravages of time. Promoting the pathway not only prevented the accumulation of protein aggregates but also significantly extended the average lifespan. "Our experiments show for the first time genetically that autophagy can sequester and eliminate misfolded and damaged proteins, which accumulate in neurons as normal part of the aging process," says Simonsen...Insulin signaling and caloric restriction are two major determinants of longevity and they also impact the activity level of autophagy. Therefore, regulating autophagy, the pathway that directly does the cleanup work, may be the key factor in controlling the aging process..."By maintaining the expression of a rate-limiting autophagy gene in the aging nervous system there is a dramatic extension of lifespan and resistance to age-associated oxidative stress," says Finley."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Friday, December 7, 2007
Extract of Rhodiola Found To Increase Lifespan of flies
Extract of Rhodiola Found To Increase Lifespan - Science Daily
Via QualityCounts
2007.12.05
"...Flies that ate a diet rich with Rhodiola rosea, an herbal supplement long used for its purported stress-relief effects, lived on an average of 10 percent longer than fly groups that didn’t eat the herb...“Although this study does not present clinical evidence that Rhodiola can extend human life, the finding that it does extend the lifespan of a model organism, combined with its known health benefits in humans, make this herb a promising candidate for further anti-aging research,” said Mahtab Jafari...the UC Irvine researchers fed adult fruit fly populations diets supplemented at different dose levels with four herbs known for their anti-aging properties. The herbs were mixed into a yeast paste, which adult flies ate for the duration of their lives. Three of the herbs – known by their Chinese names as Lu Duo Wei, Bu Zhong Yi Qi Tang and San Zhi Pian – had no effect on fruit fly longevity, while Rhodiola was found to significantly reduce mortality. On average, Rhodiola increased survival 3.5 days in males and 3.2 days in females...Jafari said she is evaluating the molecular mechanism of Rhodiola by measuring its impact on energy metabolism, oxidative stress and anti-oxidant defenses in fruit flies. She is also beginning studies in mice and in mouse and human cell cultures. These latter studies should help understand the benefits of Rhodiola seen in human trials..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Via QualityCounts
2007.12.05
"...Flies that ate a diet rich with Rhodiola rosea, an herbal supplement long used for its purported stress-relief effects, lived on an average of 10 percent longer than fly groups that didn’t eat the herb...“Although this study does not present clinical evidence that Rhodiola can extend human life, the finding that it does extend the lifespan of a model organism, combined with its known health benefits in humans, make this herb a promising candidate for further anti-aging research,” said Mahtab Jafari...the UC Irvine researchers fed adult fruit fly populations diets supplemented at different dose levels with four herbs known for their anti-aging properties. The herbs were mixed into a yeast paste, which adult flies ate for the duration of their lives. Three of the herbs – known by their Chinese names as Lu Duo Wei, Bu Zhong Yi Qi Tang and San Zhi Pian – had no effect on fruit fly longevity, while Rhodiola was found to significantly reduce mortality. On average, Rhodiola increased survival 3.5 days in males and 3.2 days in females...Jafari said she is evaluating the molecular mechanism of Rhodiola by measuring its impact on energy metabolism, oxidative stress and anti-oxidant defenses in fruit flies. She is also beginning studies in mice and in mouse and human cell cultures. These latter studies should help understand the benefits of Rhodiola seen in human trials..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Common Household Chemical BBP Could Raise Breast Cancer Risk
Common Household Chemical Could Raise Breast Cancer Risk - Yahoo Health
2007.12.06
"A chemical found in many plastic products used in households caused accelerated breast development and genetic changes in newborn female lab rats, a condition that might predispose the animals to breast cancer later in life...Butyl benzyl phthalate (BBP) is commonly used to soften polymers and plastics. It's found in everything from plastic pipes, vinyl floor tiles and carpet backing to lipstick. BBP has also been found to be an endocrine disruptor, which mimics the effect of hormones. Endocrine disruptors are known to damage wildlife and have also been implicated in reduced sperm counts and neurological problems in humans..."Our study is the first one demonstrating that exposure to this compound (BBP) soon after birth results in alterations in the expression of genes present in the mammary gland," said lead researcher Dr. Jose Russo... in March, a study published in the journal Environmental Health Perspectives suggested that exposure to phthalates could be fueling the obesity epidemic by contributing to abdominal obesity and insulin resistance in men."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.06
"A chemical found in many plastic products used in households caused accelerated breast development and genetic changes in newborn female lab rats, a condition that might predispose the animals to breast cancer later in life...Butyl benzyl phthalate (BBP) is commonly used to soften polymers and plastics. It's found in everything from plastic pipes, vinyl floor tiles and carpet backing to lipstick. BBP has also been found to be an endocrine disruptor, which mimics the effect of hormones. Endocrine disruptors are known to damage wildlife and have also been implicated in reduced sperm counts and neurological problems in humans..."Our study is the first one demonstrating that exposure to this compound (BBP) soon after birth results in alterations in the expression of genes present in the mammary gland," said lead researcher Dr. Jose Russo... in March, a study published in the journal Environmental Health Perspectives suggested that exposure to phthalates could be fueling the obesity epidemic by contributing to abdominal obesity and insulin resistance in men."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Exercise pill hope for depression
Exercise pill hope for depression - BBC News
2007.12.05
"While the link between exercise and improved mood is well known, the reasons behind it are not fully understood. The latest research focuses on an area of the brain called the hippocampus, which is already established as a target for antidepressant drugs. The team developed a test to see which genes in this region were made more active during exercise, and highlighted one called VGF. This gene is linked to a "growth factor" chemical involved in the development of nerve cells. This fitted with their theory that, for depression to lift, changes in the actual structure and links between brain cells are needed, not just changes in the chemicals surrounding the cells. The next step was to make a version of that chemical, and to test it on mice, where it showed an effect on their behaviour that roughly equated to antidepressant effects in humans. The researchers believe that a drug based on VGF could offer "possibly even superior efficacy" to current antidepressants. Marcus Roberts, Head of Policy at Mind, said that, currently, the use of exercise as a treatment for mental health problems should be recommended by doctors."Mind has long recommended physical exercise as a way of improving mental wellbeing, and many people who experience mental distress have told us that exercise has hugely benefited their mental health. "Our own research has shown that outdoor exercise can decrease feelings of depression and increase self-esteem by inspiring a sense of achievement - the evidence is growing that this should be treated as a clinically valid treatment." "
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.05
"While the link between exercise and improved mood is well known, the reasons behind it are not fully understood. The latest research focuses on an area of the brain called the hippocampus, which is already established as a target for antidepressant drugs. The team developed a test to see which genes in this region were made more active during exercise, and highlighted one called VGF. This gene is linked to a "growth factor" chemical involved in the development of nerve cells. This fitted with their theory that, for depression to lift, changes in the actual structure and links between brain cells are needed, not just changes in the chemicals surrounding the cells. The next step was to make a version of that chemical, and to test it on mice, where it showed an effect on their behaviour that roughly equated to antidepressant effects in humans. The researchers believe that a drug based on VGF could offer "possibly even superior efficacy" to current antidepressants. Marcus Roberts, Head of Policy at Mind, said that, currently, the use of exercise as a treatment for mental health problems should be recommended by doctors."Mind has long recommended physical exercise as a way of improving mental wellbeing, and many people who experience mental distress have told us that exercise has hugely benefited their mental health. "Our own research has shown that outdoor exercise can decrease feelings of depression and increase self-esteem by inspiring a sense of achievement - the evidence is growing that this should be treated as a clinically valid treatment." "
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Honey beats medicine at curing coughs
Honey beats medicine at curing coughs - NutraIngredients.com
2007.12.05
"New research from the US suggests that naturally occurring honey may ease coughs and respiratory illnesses in children more effectively than over the counter medicines...scientists from the Penn State College of Medicine researchers asked parents to give either honey, honey flavoured dextromethorphan (DM), or no treatment to 105 children, between the ages of 2 and 18 children, all suffering from nocturnal coughs...Based on parental "symptom points", children treated with honey improved by an average of 10.71 points compared with 8.39 points for DM-treated children and 6.41 points for those who were not treated..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.05
"New research from the US suggests that naturally occurring honey may ease coughs and respiratory illnesses in children more effectively than over the counter medicines...scientists from the Penn State College of Medicine researchers asked parents to give either honey, honey flavoured dextromethorphan (DM), or no treatment to 105 children, between the ages of 2 and 18 children, all suffering from nocturnal coughs...Based on parental "symptom points", children treated with honey improved by an average of 10.71 points compared with 8.39 points for DM-treated children and 6.41 points for those who were not treated..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
B vitamins vital before conception
B vitamins vital before conception - NutraIngredients.com
2007.12.06
"The importance of B vitamins, particularly folate, in foetal development is well established. The new study expands our understanding of the potential of pre-conception diets to influence the health of offspring...."The data provide the first evidence that clinically relevant reductions in specific dietary inputs to the methionine/folate cycles during the periconceptional period can lead to widespread epigenetic alterations to DNA methylation in offspring, and modify adult health-related phenotypes," wrote lead author Kevin Sinclair...The authors explain that DNA methylation is key to the maintenance of gene silencing. The process relies on a dietary supply of methyl groups, as provided by B vitamins."
The study was on sheep, but plenty of studies show a similar effect in a variety of mammals including humans.
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.06
"The importance of B vitamins, particularly folate, in foetal development is well established. The new study expands our understanding of the potential of pre-conception diets to influence the health of offspring...."The data provide the first evidence that clinically relevant reductions in specific dietary inputs to the methionine/folate cycles during the periconceptional period can lead to widespread epigenetic alterations to DNA methylation in offspring, and modify adult health-related phenotypes," wrote lead author Kevin Sinclair...The authors explain that DNA methylation is key to the maintenance of gene silencing. The process relies on a dietary supply of methyl groups, as provided by B vitamins."
The study was on sheep, but plenty of studies show a similar effect in a variety of mammals including humans.
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Folate may reduce depression symptoms for men, says study
Folate may reduce depression symptoms for men, says study - NutraIngredients.com
2007.12.07
"Increased intake of folate may reduce the incidence of depression amongst by 50 per cent, suggests a new study of over 500 Japanese subjects.The benefits were not extended to women...The research adds to a growing body of research linking folate and folic acid intake to improved mood, and follows a review by scientists at the University of York and Hull York Medical School of 11 studies and involving 15,315 participants that reported low folate levels were linked to increased depression ...male subjects with the highest average intake (235 micrograms per 100 kcal) were 50 per cent less likely to have depressive symptoms than men with the lowest average intake (119 micrograms per 100 kcal)...No statistically significant links were reported between depressive symptoms and intakes of riboflavin, pyridoxine, cobalamin, and all or individual omega-3 fatty acids, for either sex..."
Although keep in mind that folic acid has been linked to an increase in cancer. Key quote - "Exposure to high intakes of folic acid in early life and young adulthood may provide life-long protection from the tendency for cancer formation in different organs, such as the large intestines, whereas such exposures later in life, when cell damage has occurred, can spur on the advance of the tumor."
So what's the answer? Eat the natural form - folate, in your diet, and skip the supplement Folic acid. "Folic acid is a synthetic form of folate, a B vitamin found in a wide variety of foods including liver and green leafy vegetables. Folates are metabolised in the gut, whereas in a paper to be published in the British Journal of Nutrition in October IFR scientists suggest that folic acid is metabolised in the liver. The liver is an easily saturated system, and fortification could lead to significant unmetabolised folic acid entering the blood stream, with the potential to cause a number of health problems."
NIH info sheet on Folate
"Selected Food Sources of Folate and Folic Acid [5]
"
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.07
"Increased intake of folate may reduce the incidence of depression amongst by 50 per cent, suggests a new study of over 500 Japanese subjects.The benefits were not extended to women...The research adds to a growing body of research linking folate and folic acid intake to improved mood, and follows a review by scientists at the University of York and Hull York Medical School of 11 studies and involving 15,315 participants that reported low folate levels were linked to increased depression ...male subjects with the highest average intake (235 micrograms per 100 kcal) were 50 per cent less likely to have depressive symptoms than men with the lowest average intake (119 micrograms per 100 kcal)...No statistically significant links were reported between depressive symptoms and intakes of riboflavin, pyridoxine, cobalamin, and all or individual omega-3 fatty acids, for either sex..."
Although keep in mind that folic acid has been linked to an increase in cancer. Key quote - "Exposure to high intakes of folic acid in early life and young adulthood may provide life-long protection from the tendency for cancer formation in different organs, such as the large intestines, whereas such exposures later in life, when cell damage has occurred, can spur on the advance of the tumor."
So what's the answer? Eat the natural form - folate, in your diet, and skip the supplement Folic acid. "Folic acid is a synthetic form of folate, a B vitamin found in a wide variety of foods including liver and green leafy vegetables. Folates are metabolised in the gut, whereas in a paper to be published in the British Journal of Nutrition in October IFR scientists suggest that folic acid is metabolised in the liver. The liver is an easily saturated system, and fortification could lead to significant unmetabolised folic acid entering the blood stream, with the potential to cause a number of health problems."
NIH info sheet on Folate
"Selected Food Sources of Folate and Folic Acid [5]
| Food | Micrograms (μg) | % DV^ |
|---|---|---|
| *Breakfast cereals fortified with 100% of the DV, ¾ cup | 400 | 100 |
| Beef liver, cooked, braised, 3 ounces | 185 | 45 |
| Cowpeas (blackeyes), immature, cooked, boiled, ½ cup | 105 | 25 |
| *Breakfast cereals, fortified with 25% of the DV, ¾ cup | 100 | 25 |
| Spinach, frozen, cooked, boiled, ½ cup | 100 | 25 |
| Great Northern beans, boiled, ½ cup | 90 | 20 |
| Asparagus, boiled, 4 spears | 85 | 20 |
| *Rice, white, long-grain, parboiled, enriched, cooked, ½ cup | 65 | 15 |
| Vegetarian baked beans, canned, 1 cup | 60 | 15 |
| Spinach, raw, 1 cup | 60 | 15 |
| Green peas, frozen, boiled, ½ cup | 50 | 15 |
| Broccoli, chopped, frozen, cooked, ½ cup | 50 | 15 |
| *Egg noodles, cooked, enriched, ½ cup | 50 | 15 |
| Broccoli, raw, 2 spears (each 5 inches long) | 45 | 10 |
| Avocado, raw, all varieties, sliced, ½ cup sliced | 45 | 10 |
| Peanuts, all types, dry roasted, 1 ounce | 40 | 10 |
| Lettuce, Romaine, shredded, ½ cup | 40 | 10 |
| Wheat germ, crude, 2 Tablespoons | 40 | 10 |
| Tomato Juice, canned, 6 ounces | 35 | 10 |
| Orange juice, chilled, includes concentrate, ¾ cup | 35 | 10 |
| Turnip greens, frozen, cooked, boiled, ½ cup | 30 | 8 |
| Orange, all commercial varieties, fresh, 1 small | 30 | 8 |
| *Bread, white, 1 slice | 25 | 6 |
| *Bread, whole wheat, 1 slice | 25 | 6 |
| Egg, whole, raw, fresh, 1 large | 25 | 6 |
| Cantaloupe, raw, ¼ medium | 25 | 6 |
| Papaya, raw, ½ cup cubes | 25 | 6 |
| Banana, raw, 1 medium | 20 | 6 |
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Green tea may protect against colon cancer
Green tea may protect against colon cancer - Yahoo! News
2007.12.07
"...a standardized green tea polyphenol preparation (Polyphenon E) limits the growth of colorectal tumors in rats treated with a substance that causes the cancer..."Our findings show that rats fed a diet containing Polyphenon E are less than half as likely to develop colon cancer," Dr. Hang Xiao...The amount of Polyphenon the animals took in was roughly equal to about four to six cups of green tea per day...Polyphenon E decreased the total number of tumors per rat and decreased tumor size, compared with control rats that were not given Polyphenon E..."In the control group," he said, "67 percent of rats developed malignant tumors while in the treated group only 27 percent of rats had malignant tumors. Most important, tea polyphenols decreased the number of malignant tumors per rat by 80 percent compared to the control group."..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.07
"...a standardized green tea polyphenol preparation (Polyphenon E) limits the growth of colorectal tumors in rats treated with a substance that causes the cancer..."Our findings show that rats fed a diet containing Polyphenon E are less than half as likely to develop colon cancer," Dr. Hang Xiao...The amount of Polyphenon the animals took in was roughly equal to about four to six cups of green tea per day...Polyphenon E decreased the total number of tumors per rat and decreased tumor size, compared with control rats that were not given Polyphenon E..."In the control group," he said, "67 percent of rats developed malignant tumors while in the treated group only 27 percent of rats had malignant tumors. Most important, tea polyphenols decreased the number of malignant tumors per rat by 80 percent compared to the control group."..."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Studies show how fruits and veggies reduce cancer
Studies show how fruits and veggies reduce cancer - Yahoo! News
2007.12.07
"Just three servings a month of raw broccoli or cabbage can reduce the risk of bladder cancer by as much as 40 percent...These foods are rich in compounds called isothiocyanates, which are known to lower cancer risk..."Cooking can reduce 60 to 90 percent of ITCs, (isothiocyanates)," Dr. Li Tang...A second team of researchers from Roswell Park tested broccoli sprouts in rats.They used rats engineered to develop bladder cancer and fed some of them a freeze-dried extract of broccoli sprouts. The more they ate, the less likely they were to develop bladder cancer, said Dr. Yuesheng Zhang"...In a third study, a team at The Ohio State University fed black raspberries to patients with Barrett's esophagus, a condition that can lead to esophageal cancer...Ohio State's Laura Kresty and colleagues fed 1.1 ounces (32 grams) of freeze-dried black raspberries to women with Barrett's esophagus and 1.6 ounces (45 grams) to men every day for six months...They measured urine levels of levels of two compounds -- 8-isoprostane and GSTpi -- that indicate whether cancer-causing processes are going on in the body...Kresty said 58 percent of patients had marked declines of 8-isoprostane levels, suggesting less damage, and 37 percent had higher levels of GSTpi, which can help interfere with cancer causing damage and which is usually low in patients with Barrett's."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.07
"Just three servings a month of raw broccoli or cabbage can reduce the risk of bladder cancer by as much as 40 percent...These foods are rich in compounds called isothiocyanates, which are known to lower cancer risk..."Cooking can reduce 60 to 90 percent of ITCs, (isothiocyanates)," Dr. Li Tang...A second team of researchers from Roswell Park tested broccoli sprouts in rats.They used rats engineered to develop bladder cancer and fed some of them a freeze-dried extract of broccoli sprouts. The more they ate, the less likely they were to develop bladder cancer, said Dr. Yuesheng Zhang"...In a third study, a team at The Ohio State University fed black raspberries to patients with Barrett's esophagus, a condition that can lead to esophageal cancer...Ohio State's Laura Kresty and colleagues fed 1.1 ounces (32 grams) of freeze-dried black raspberries to women with Barrett's esophagus and 1.6 ounces (45 grams) to men every day for six months...They measured urine levels of levels of two compounds -- 8-isoprostane and GSTpi -- that indicate whether cancer-causing processes are going on in the body...Kresty said 58 percent of patients had marked declines of 8-isoprostane levels, suggesting less damage, and 37 percent had higher levels of GSTpi, which can help interfere with cancer causing damage and which is usually low in patients with Barrett's."
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
Tuesday, December 4, 2007
Fitness level is predictor of longevity
Fitness Level, Not Body Fat, May Be Stronger Predictor Of Longevity For Older Adults ScienceDaily
2007.12.05
"Adults over age 60 who had higher levels of cardiorespiratory fitness lived longer than unfit adults, independent of their levels of body fat... Fit participants had lower death rates than unfit participants within each stratum of adiposity, except for two of the obesity groups. In most instances, death rates for those with higher fitness were less than half of rates for those who were unfit..."Our data provide further evidence regarding the complex long-term relationship among fitness, body size, and survival. It may be possible to reduce all-cause death rates among older adults, including those who are obese, by promoting regular physical activity, such as brisk walking for 30 minutes or more on most days of the week (about 8 kcal/kg per week), which will keep most individuals out of the low-fitness category. Enhancing functional capacity also should allow older adults to achieve a healthy lifestyle and to enjoy longer life in better health.""
"DogVitals powerful antioxidant supplement for dogs - helping dogs live a younger, healthier life
2007.12.05
"Adults over age 60 who had higher levels of cardiorespiratory fitness lived longer than unfit adults, independent of their levels of body fat... Fit participants had lower death rates than unfit participants within each stratum of adiposity, except for two of the obesity groups. In most instances, death rates for those with higher fitness were less than half of rates for those who were unfit..."Our data provide further evidence regarding the complex long-term relationship among fitness, body size, and survival. It may be possible to reduce all-cause death rates among older adults, including those who are obese, by promoting regular physical activity, such as brisk walking for 30 minutes or more on most days of the week (about 8 kcal/kg per week), which will keep most individuals out of the low-fitness category. Enhancing functional capacity also should allow older adults to achieve a healthy lifestyle and to enjoy longer life in better health.""
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