Thursday, August 9, 2007

Folate may lower breast cancer risk

Increased folate may slash breast cancer risk 8/9/07 "The researchers calculated that women in the highest average intake group (456 micrograms of folate per day) had a 44 per cent lower risk of invasive breast cancer than women in the lowest average intake group (160 micrograms of folate per day)...the researchers report that the protective effect of folate only applied to the overweight women...the reduced form of folate, 5- Methyltetrahydrofolate (MTHF) plays a role in a series of reactions for DNA methylation"Changes in DNA methylation patterns are an early event in carcinogenesis and may influence gene silencing," they said. "Folate is also involved in DNA synthesis and repair; folate deficiency has been related to elevated uracil incorporation to DNA and subsequent chromosome breaks, which may contribute to an increased risk of cancer."..."Yet, there is now increasing evidence from randomized trials that high doses of folic acid can foster the growth of common precancerous lesions. The benefit of reducing a relatively small number of neural tube defects may be outweighed by the possible negative effects on tumor promotion in a substantial fraction of the population. ..."

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