Wednesday, October 3, 2007

Red Wine Ingredient -- Resveratrol -- Fights Diabetes In Mice

ScienceDaily: Red Wine Ingredient -- Resveratrol -- Fights Diabetes In Mice
"...Even relatively low doses of resveratrol--a chemical found in the skins of red grapes and in red wine--can improve the sensitivity of mice to the hormone insulin, according to a new report. As insulin resistance is often characterized as the most critical factor contributing to the development of type 2 diabetes, the findings "provide a potential new therapeutic approach for preventing or treating" both conditions...also confirmed that increased levels of an enzyme called SIRT1, which earlier studies had linked to longevity, DNA repair, and insulin secretion, improve insulin sensitivity in mice. Resveratrol is known to activate the SIRT1 enzyme...SIRT1 levels are reduced in insulin-resistant cells and tissues and that treatments that block the enzyme's function lead to insulin resistance. Furthermore, increased SIRT1 activity improved insulin sensitivity. Similarly, resveratrol--at a dose of just 2.5 mg/kg/day--enhanced insulin sensitivity in cells. That low dose of resveratrol also reduced insulin resistance in animals fed a high-fat diet...about 15 mg--for its biological effects..."

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