Wednesday, April 18, 2007

Low vitamin D and cancer risk

Low vitamin D levels again linked to cancer risk 4/17/07 "Vitamin D deficiency is linked to an increased risk of cancer, researchers have told attendees at the annual meeting of the American Association for Cancer Research, with results from a clinical trial hoped to show benefits of high-dose vitamin D replacement in individuals with high risk of lung cancer...Preclinical studies have demonstrated an anti-proliferative and pro-differentiative effects of high-dose 1,25(OH)2D in vitro and in vivo, said Trump, with all tumour models sensitive to vitamin D...Calls to increase vitamin D intake have been growing. Indeed, only recently fifteen experts from universities, research institutes, and university hospitals around the world called for international agencies to "reassess as a matter of high priority" dietary recommendations for vitamin D because current advice is outdated and puts the public at risk of deficiency (The American Journal of Clinical Nutrition, Vol. 85, pp. 860-868)...A recent review of the science reported that the tolerable upper intake level for oral vitamin D3 should be increased five-fold, from the current tolerable upper intake level (UL) in Europe and the US of 2000 International Units (IU), equivalent to 50 micrograms per day, to 10,000 IU (250 micrograms per day)..."

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