Tuesday, May 22, 2007

Anti-cancer Triterpenoids From Apple Peel

Scientists Isolate Anti-cancer Compounds From Apple Peel ScienceDaily 5/22/07 "Until now, however, scientists had not identified the specific phytochemicals responsible for apple's anti-cancer effects. Xiangjiu He and Liu processed 231 pounds of Red Delicious apples and extracted phytochemicals from about 24 pounds of peel. They screened the compounds for anti-cancer effects in laboratory cultures of human liver, breast, and colon cancer cells. In doing so, they identified a group of compounds with "potent" anti-cancer effects.Article: "Triterpenoids isolated from Apple Peels Have Potent Antiproliferative Activity and May be Partially Responsible for Apple's Anticancer Activity" "

More in the abstract below

Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity ACS publications 5/8/07 "All triterpenoids tested showed antiproliferative activity against Caco-2 cancer cells, especially 2-hydroxyursolic acid, maslinic acid, 2-hydroxy-3-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3-trans-p-coumaroyloxy-2-hydroxyolean-12-en-28-oic acid, which displayed much higher antiproliferative activities. These results showed the triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for the anticancer activities of whole apples. "

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