Thursday, May 31, 2007

Omega 3 linked to stronger bones

Fish oil again linked to stronger bones 5/31/07 "Increasing omega-3 fatty acid intake in the diet at the expense of omega-6 fatty acids may boost bone health and reduce the risk of osteoporosis later in life, if a new study in mice can be translated into humans...In the fish oil-supplemented mice, bone mineral density increased significantly in distal femoral metaphysis (DFM) by 20 per cent, proximal tibial metaphysis (PTM) by 24 per cent and tibial diaphysis (TD) by 15 per cent, versus baseline. In comparison, BMD increased only minimally in corn oil-fed mice. BMD increased significantly in the femoral diaphysis (FD) bone region in mice groups, but the increase was higher in fish oil-supplemented mice compared to the corn oil-fed mice, 36 versus 25 per cent, respectively...The beneficial findings amongst the fish oil-fed mice was also accompanied by a decreased activity of pro-inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and lower osteoclast generation in bone marrow cell cultures...Inflammation is caused by a number of compounds, including cytokines. These compounds also stimulate bone breakdown, a natural part of a body process known as the bone cycle in which they are continuously broken down and rebuilt."Inhibition of pro-inflammatory cytokines and lower osteoclast generation suggest that higher BMD in FO-fed mice may be associated, in part, with both decreased bone resorption and higher bone formation," concluded the researchers. "

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