Antioxidants Decrease Disease In Fruit Fly Model Of Alzheimer's Disease

Antioxidants Decrease Disease In Fruit Fly Model Of Alzheimer's Disease ScienceDaily 12/15/06 "Alzheimer's disease (AD) is one of a number of neurodegenerative disorders in which brain cells damaged by naturally occurring chemicals known as reactive oxygen species (ROS) have been observed. However, whether this oxidative damage causes neurodegeneration or is a consequence of it has not been previously determined...A study appearing online on December 14, in advance of publication in the January print issue of the Journal of Clinical Investigation, indicates that oxidative damage is a factor contributing to neurodegeneration in a Drosophila model of neurodegenerative disorders such as AD. - Mel Feany and colleagues from Brigham and Women's Hospital and Harvard Medical School"

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Synthetic marijuana helps cancer patients - also helps symptoms of pain, anxiety and depression

Synthetic marijuana helps cancer patients Reuters via Yahoo!News 12/15/06 "The drug is part of a class known as cannabinoids that are similar to the active ingredient found in naturally occurring cannabis, or marijuana...those treated with the drug experienced significantly more pain reduction than patients treated with standard therapy. Scores for drowsiness, tiredness, appetite and well-being were stable in the Cesamet group, but deteriorated in the non-Cesamet group.
Depression and anxiety were also reduced significantly in the nabilone group, but increased in the non-cannabinoid group..."The findings show how great the potential is to improve the quality of life for cancer patients," said lead investigator Dr. Vincent Maida of the University of Toronto"

The broad spectrum benefits makes you wonder what off prescription uses this medication might find. This was a small study and we'll see in the future if under more rigorous studies it offers such great utility.

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reversing diabetes

Researchers reverse diabetes in mice Reuters via Yahoo!News 12/15/06 "Defective nerve endings may attract immune system proteins that mistakenly attack the pancreas, destroying its ability to make insulin, the researchers said. This destruction is what causes diabetes...Injecting a piece of protein, or peptide, to repair the defect cured diabetic mice "overnight," Dr. Hans Michael Dosch of the University of Toronto said... The team will soon begin clinical studies on people whose family history suggests they are at risk of developing type-1 diabetes to see if their sensory nerves work well...If they do not, Dosch said, that would suggest the bad nerve endings were a cause of diabetes, not only an effect as has been widely assumed...Trials could then begin injecting peptides into patients with diabetes or those at high risk. It could take a number of years, Dosch said.
He said the findings might also hold promise for type-2 diabetes -- which affects about 10 times as many people as type-1 -- though the results were not as strong"

Very encouraging news for type-1 diabetes and possibly for type-2. There's more in the article about implications of the research for type-2 diabetes.

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Breast Cancer Rates Fall Sharply

7% Decline Attributed to Drop in Hormone Replacement Therapy WebMD 12/14/06 "That means as many as 14,000 fewer women were diagnosed with breast cancer in 2003 than in 2002, a year in which the American Cancer Society estimates there were 203,500 new cases, says researcher Donald Berry, PhD, a biostatistician at The University of Texas M.D. Anderson Cancer Center in Houston...."

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World's oldest person dies at 116

Elizabeth "Lizzy" Bolden died at a nursing home in Memphis, Tennessee. BBC News 12/12/06 "Mrs Bolden had 40 grandchildren, 75 great-grandchildren, 150 great-great-grandchildren, 220 great-great-great grandchildren and 75 great-great-great-great grandchildren. She assumed the title of world's oldest person following the death of Esther de Capovilla of Ecuador in August - also at the age of 116. Her successor looks set to be Emiliano Mercado del Toro of Puerto Rico, who is 115, according to Robert Young, adviser to Guinness World Records. "

There's no first person advice on how to live to a "ripe old age" that you usually find in such articles. It's usually amusing to get health bromides as hard work, spirituality and a good attitude. And hey they might help... a bit. More likely it was great genes and lots of luck.

I included the above quote because holy moses... if you live enough and breed a bit you get a small country's worth of descendants.

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Height loss link to heart disease

Losing 3cm or more might equal heart disease BBC News 12/12/06 "those who lost 3cm in height were 64% more likely to die than those who lost less than 1cm...Height loss was associated with a 42% increased risk of coronary events such as heart attacks, even in men who had no history of cardiovascular disease...study leader Dr Goya Wannamethee, reader in epidemiology at the Royal Free and University College Medical School in London, said osteoporosis was associated with more severe height loss - generally 6cm. "It's been well established that shortness is associated with cardiovascular disease, so we were interested to see whether height loss itself could influence mortality," she said. "It's another indicator of poor health," she concluded. "Even fairly benign height loss." "

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Male circumcision 'cuts' HIV risk

Circumcision can cut the rate of HIV infection in heterosexual men by 50% BBC News 12/13/06 "The trial in Kenya found a 53% reduction in new HIV infections in heterosexual men who were circumcised while the Ugandan study reported a drop of 48%. Results last year from a study in 3,280 heterosexual men in South Africa, which was also stopped early, showed a 60% drop in the incidence of new infections in men who had been circumcised... Specific cells in the foreskin may be potential targets for HIV infection and also the skin under the foreskin becomes less sensitive and is less likely to bleed reducing risk of infection following circumcision..."

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Possible preventitive agent for bird flu

Novel Peptide Targets Viral Cells And May Inhibit Influenza Virus Infection ScienceDaily 12/13/06 "In the study researchers tested the newly identified peptide, EB (entry blocker), for antiviral activity against influenza viruses including the H5N1 strain in mice. Results showed the peptide capable of inhibiting viral attachment to the cellular receptor ultimately preventing infection...(J.C. Jones, E.A. Turpin, H. Bultmann, C.R. Brandt, S. Schultz-Cherry. 2006. Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. Journal of Virology, 80. 24: 11960-11967.)"

Now will it work for humans? Is it safe? Can we mass produce it and how much will it cost? Lots of questions. I hope they get the funding to quickly answer all of these.

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Future cure for alcoholics?

Research Offers Hope For Alcoholics ScienceDaily 12/13/06 "In studies conducted with rats, Dr Andrew Lawrence and his Florey colleagues used a drug that blocked Orexin's euphoric effects in the brain and the results were remarkable. "In one experiment, rats that had alcohol freely available to them stopped drinking it after receiving the Orexin blocker."... "Orexin reinforces the euphoria felt when drinking alcohol, so if a drug can be developed to block the Orexin system in humans, we should be able to stop an alcoholic's craving for alcohol, as well as preventing relapse once the alcoholic has recovered," he said.
Dr Lawrence said that this research could also lead to treatments for eating disorders, such chronic over-eating, which leads to obesity..."Before a therapeutic Orexin-blocking drug can be developed, we need to ensure that it will be safe to use in the long-term and that issues surrounding a person's compliance in taking the drug are considered,""

Obviously the cure will not be around in the next 5 years due to future research and then trials. But maybe within 10yrs. I see research like this and I wonder why we waste money in other areas of government. A few decades ago it used to be that money wasn't necessarily a research accelerator. I don't think that can be said now. Too bad most in the public do not understand this... otherwise reallocation of funds toward research on various diseases might occur and faster progress towards cures.

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infections related to brain cancer

Number Of Siblings Predicts Risk Of Brain Tumors ScienceDaily 12/12/06 "The population-based study, the largest of its kind, analyzed 13,613 brain tumor cases in Sweden. It found people with four or more siblings were twice as likely to develop a brain tumor as people with no siblings..."Since the size of a family and the number of younger siblings correlate with the incidence of brain tumors, this suggests infectious agents may be causing the disease," said study author Andrea Altieri, DSc, with the German Cancer Research Center in Heidelberg, Germany...the finding that brain tumor rates were higher among people with younger siblings, and not older siblings, suggests infections or re-infections in late childhood may play an important role in causing the disease, while exposure to infections in infancy, birth to five months old, may be beneficial"

Could this be more evidence for the viruses help cause some cancers theory? Interesting that they mention that infections from birth to 5 months seem beneficial but those after not so much - possibly harmful.

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Folic acid won't cut heart, stroke risk

Folic acid will not cut heart and stroke risk. Reuters via Yahoo!News 12/12/06 ""We found that there was no benefit to using folic acid supplements in terms of cardiovascular disease risk or stroke risk," ...Researchers led by Dr. Lydia Bazzano of Tulane University School of Public Health and Tropical Medicine in New Orleans analyzed the results of 12 trials conducted since 2002 involving nearly 17,000 people..."Really, what you should be doing are things like quitting smoking, increasing your exercise if you can, lowering your blood pressure, lowering your cholesterol."

Besides exercise and a change in diet, aspirin can help lower the heart, stroke risk.

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Exercise and breast cancer and bone loss

may help prevent breast cancer and can be a safer way to lose weight Reuters/Yahoo!News 12/11/06 "One report from the Mayo Clinic College of Medicine in Rochester, Minnesota, said a study of women aged 55 to 69 found that those with the highest physical activity levels when the study began had a 14 percent lower risk of developing breast cancer than those who got low levels of exercise...In another study published in the same journal, doctors at Washington University School of Medicine in St. Louis found that people who slim down by cutting calories may also be losing bone density -- something that does not happen if weight loss comes through exercise"


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Moderate alcohol use extends life

Those 2 glasses a day that lengthen your life EurekAlert! 12/11/06 "A study performed by the Research Laboratories of the Catholic University of Campobasso (Italy) con-firms the beneficial effects that moderate consumption of alcohol has on our health...drinking in moderation reduces all-cause mortality..."Our data- says Augusto Di Castelnuovo, lead author of the study - show that consumption of little amounts of alcohol leads to a reduction of mortality up to 18%. But after a certain number of glasses things radically change: who drinks too much not only looses this advantage, but increases his own risk of death in relation to the amount of alcohol consumed"...Whereas men report a beneficial effect after consuming 2-4 doses maximum (a dose refers to one glass of wine or beer), women should be aware: for them, the protection guaranteed from alcohol consumption disappears just after two glasses a day"

What's the risk of drinking too much? Well there's always a risk that you will wake up after a bender with your eyebrows shaved off... . Actually you'll be more likely to get liver disease and a variety of cancers. So 2-4 drinks for a man and 2 drinks for a woman is the general rule that this study encourages.

The study indicates that Europeans seem to gain more health benefits from moderate drinking than Americans and that might be because they drink more red wine - although that was not in the purview of the study.

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More on health benefits of Vitamin D

Almost everyone needs more of the sunshine vitamin USNews&WR 12/18/06 "A single nutrient that keeps bones strong, wards off diabetes, and protects against tuberculosis, cancer, colds, and the flu. Sound too good to be true? There's more: It's free. But you're almost certainly not getting enough...Prior to the industrial revolution, humans had no trouble getting an abundance of the sunshine vitamin; a mere 10 to 15 minutes outdoors at midday gives the average fair-skinned person 10,000 international units. That's far above the government's dietary recommendations of 200 IUs a day up to age 50, 400 IUs to age 70, and 600 IUs over 70... A review of more than 100 studies on vitamin D and respiratory diseases, published in the current Epidemiology and Infection, found that low levels probably allow the viruses to penetrate the immune system...With cancer, it's thought that vitamin D might prevent tumors from rapidly growing by controlling the expression of certain genes that regulate cell division"

This is a vitamin D renaissance. More on Vit D later.

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Body temperature and life extension

Reducing body temperature extends life span of mice Reuters via ABCNews 11/2/06 "Lowering the body temperature of mice extended their life span by up to 20 percent..."We are showing that there is a way to obtain the benefit on life span and aging that are known to be conferred by calorie restrictions without necessarily undergoing calorie restrictions," lead researcher Bruno Conti of the Scripps Research Institute... Median life span in females was extended by about 20 percent and in males by about 12 percent"

If this proves true for us then it appears we have two ways to dramatically extend life, eat hardly a thing, or live cold. Very appealing.

Of course there might be other ways and my hope is that a synthetic version of resveratrol will do the trick and then we get to eat what we like and wear sweaters.

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Eat slow to eat less

Eating slowly really does make people eat less Reuters via SciAm 12/1/06 "Women consumed about 70 fewer calories when they were told to take their time eating a meal of pasta and sauce, compared to when they were instructed to eat it as quickly as possible. They also rated the meal as more pleasant when they ate slowly.
"They got more pleasure for (fewer) calories, and more satiety for (fewer) calories," Dr. Kathleen Melanson of the University of Rhode Island in Kingston...When eating quickly, the women took in an average of 646 calories in nine minutes. But when they slowed down, they consumed 579 calories in 29 minutes"

It's a very small study, but doesn't it makes sense in your own experience? Eating slowly usually means you eat less. And what it does is to allow for gut hormones leptin, cholecystokinin PYY3-36, etc. to begin signalling a sense of fullness in the brain. Of course try to eat good fresh pizza slow. I challenge you.

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Protein and cancer

Does Too Much Protein In The Diet Increase Cancer Risk? ScienceDaily 12/7/06 "American Journal of Clinical Nutrition, shows that lean people on a long-term, low-protein, low-calorie diet or participating in regular endurance exercise training have lower levels of plasma growth factors and certain hormones linked to cancer risk... people on a low-protein, low-calorie diet had considerably lower levels of a particular plasma growth factor called IGF-1 than equally lean endurance runners," says the study's first author Luigi Fontana, M.D., Ph.D., assistant professor of medicine at Washington University and an investigator at the Istituto Superiore di Sanità in Rome, Italy. "That suggests to us that a diet lower in protein may have a greater protective effect against cancer than endurance exercise, independently of body fat mass...Data from animal studies also suggest that lower IGF-1 levels are associated with maximal lifespan..."Many people are eating too many animal products — such as meat, cheese, eggs and butter — as well as refined grains and free sugars," he says. "Our intake of vegetables and fruits is low, and beans are vastly underconsumed in the U.S. and Europe these days."

Another argument for a vegetarian, or low meat diet.

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Sea Urchin May Hold Key To Cures

Sea Urchin Genome Suprisingly Similar To Man And May Hold Key To Cures ScienceDaily 12/7/06 "...it shares a common ancestor with humans. Sea urchins are closer to human and vertebrates from an evolutionary perspective than other more widely studied animal models, such as fruit fly or worms. The purple sea urchin, in fact, has 7,000 genes in common with humans,...Of particular interest to Calestani is the way the sea urchin's immune system works. The human immune system has two components: innate immunity, with which we are born, and acquired immunity, which is the ability to produce antibodies in response to an infection. Sea urchins only have innate immunity, and it is greatly expanded with 10 to 20 times as many genes as in human.
"Considering that sea urchins have a long life span -- some can live up to 100 years -- their immune system must be powerful," Calestani said. "Sea urchins could very well provide a new set of antibiotic and antiviral compounds to fight various infectious diseases.""

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FDA Weighs Risks, Benefits of Drug-Coated Stents

FDA Weighs Risks, Benefits of Drug-Coated Stents NPR 12/7/06 "No one knows for sure why the coated stents cause these blood clots. But doctors are once again looking for a solution. One clue comes from a study at Duke University. Researchers reviewed the medical records of hundreds of people who got drug-coated stents at the medical center there.
All the patients took a drug called Plavix to reduce the chance that clots would form. That's standard practice. But patients who kept taking Plavix longer than six months were far less likely to die or have a heart attack. David Kong, a cardiologist at Duke, says that suggests that long-term use of Plavix could offset the risk of blood clots from coated stents. "

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What form of Vitamin D is best? D3

The debate over whether vitamin d is best for us in D2 (ergocalciferol) or D3 (cholecalciferol) appears to be settled with D3 appearing to be significantly more potent for us. Most supplements are D2. So if you're buying vitamin D for anti-cancer purposes, make sure it's D3 you are getting. In the abstract below you'll see that the researchers come down hard on D2 and say it isn't "suitable for supplementation or fortification."
I hope milk makers are taking note. Almost all milk is fortified with D2.

The case against ergocalciferol (vitamin D2) as a vitamin supplement Am J Clin Nutr. 2006 Oct;84(4):694-7 "vitamin D3 has proven to be the more potent form of vitamin D in all primate species, including humans...Despite an emerging body of evidence suggesting several plausible explanations for the greater bioefficacy of vitamin D3, the form of vitamin D used in major preparations of prescriptions in North America is vitamin D2. The case that vitamin D2 should no longer be considered equivalent to vitamin D3 is based on differences in their efficacy at raising serum 25-hydroxyvitamin D, diminished binding of vitamin D2 metabolites to vitamin D binding protein in plasma, and a nonphysiologic metabolism and shorter shelf life of vitamin D2. Vitamin D2, or ergocalciferol, should not be regarded as a nutrient suitable for supplementation or fortification"

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fruits, chocolate and multivitamin lowers risk of miscarriage

Fruit And Veg 'Can Halve Miscarriage Risk' Daily Mail via LEF 12/5/06 "A study of thousands of pregnant women revealed those who included fruit and veg regularly in their diet were 46 per cent less likely to miscarry...Chocolate, vitamin tablets, dairy products, fish and white meat also increased the odds of a successful pregnancy...Each year, around a quarter of a million British women face the heartache of miscarriage, with most losing their babies during the first three months of pregnancy-Researcher Dr Maureen Maconochie said: 'An estimated one in five pregnancies in the UK will end in miscarriage"

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Vitamin D fights cancer

Continuing the thread of vitamin D and cancer...

Vitamin D status and cancer: new insights. Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):6-11 VIA QualityCounts.com "SUMMARY: Studies over the past year indicate potentially important roles for vitamin D in cancer prevention, survival and treatment....Studies showing risk reduction by vitamin D in prostate, colon and breast cancers were joined by new analyses of endometrial, skin, and pancreatic cancers. Interest in vitamin D has extended to examinations of its influence on premalignant conditions such as adenomatous polyps and breast density. Studies of vitamin D and cancer survival have featured prominently in the recent literature. Sun exposure and indicators of high vitamin D status were found to be associated with improved survival for cutaneous melanoma, Hodgkin's lymphoma, and cancers of the lung, breast, prostate and colon. Therapeutic trials of vitamin D are especially prominent in the treatment of prostate cancer."

Vitamin D making a strong case for more sunshine in your life, or supplements.

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Can We Slow Aging?

A compound found in red wine may extend the human life span Newsweek 12/11/06 "Some people shudder at the thought of a treatment to extend human life, imagining that the added years would be ones of frailty and of failing intellect and strength. However, the animals that get added time from resveratrol treatment are, by all measures, remarkably vital until the end. It has been estimated that drugs that maintain health and vitality could save the U.S. economy tens of trillions of dollars. For example, a permanent 1 percent reduction in mortality from cancer would have a value to current and future generations of Americans of nearly $500 billion. Many scientists are encouraging Congress to increase funding for aging research, to launch the equivalent of the Apollo program. Only a few humans made it to the moon. In the future, millions may live a century or more, and remain vital and productive during those added years."

David Sinclair of resveratrol fame, writing in this weeks Newsweek.

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Dogs May Protect Kids From Allergies

Infants in Homes With 2 or More Dogs May Be Less Likely to Wheeze WebMD 12/5/06 "Infants who live in a house with multiple dogs may be less likely to develop allergies later in life, according to a new study..."Our bodies are programmed to produce allergic responses early in life," says David Bernstein, MD, professor of immunology at the University of Cincinnati, in a news release. "But there are environmental factors like bacterial endotoxins that may modify the immune system and block development of allergies early in life."

Very encouraging to us dog owners who are expecting.

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No Cancer Risk Seen With Cell Phones

Study Shows No Spike in Cancer Among Long-Term Cell Phone Users WebMD 12/5/06 "The study included more than 420,000 Danes who got their first cell phone between 1982 and 1995. Some of those people kept their phones as long as 21 years. But, on average, they had cell phone service for 8.5 years. The study's researchers included Joachim Schuz, PhD, of the Danish Cancer Society"



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Minnesota deemed healthiest state, Louisiana worst

Minnesota was deemed the healthiest U.S. state for the fourth year in a row Reuters/Yahoo!News 12/5/06 "The report weighed a series of factors in determining rankings, such as prevalence of obesity, smoking, infectious disease, cardiovascular deaths, infant mortality, child poverty, immunization rates, workplace deaths and auto deaths...Southern states performed particularly poorly while those in New England and some in the Upper Midwest fared well."

Very interesting report. The full version can be found here. Fish around on that page and you'll find the PDF link.

Some highlights: The good news is most causes of death are down significantly since 1990, although obesity has gotten 110% worse. Jeez louis. And a 19% increase in the uninsured population. Not good. And in the last year violent crime rose 1%.

USA is one of the worst developed countries for infant mortality - 2004 (Iceland is best). Shameful. And we're near the bottom of the list for life expectancy - 2002 - at birth - 71F 67M (Japan is best 78F 72M). Interesting to note that many of the top countries in the life expectancy category employ around 80% of medical records in an electronic format. USA is at 17%. Correlation, you bet.

Also I wonder how many people have noticed that in this study the states with the most sunny days have some of the lowest cancer rates - like Utah, Arizona, New Mexico, Colorado Hawaii. States that have less days of sunshine seem to have higher cancer rates, on average - though it's a bit uneven here. Vitamin D again?

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Poll Shows America's Elders Aging Well

Life After 80 May Be Better Than You Think, Survey Suggests WebMD 12/1/06 "half (47%) of those elders were in excellent or good physical and mental healthmental health...The poll comes when America's life expectancy is at an all-time high: nearly 78 years, according to the CDC...The 85-and-older group is expected to double from nearly 5 million in 2003 to almost 10 million in 2030 as baby boomers age, states a 2005 U.S. Census Bureau report"

Just a Gallop poll, but it is encouraging. Although the 90 and older quality of life numbers are fairly depressing. After 90 it appears that most people fall off a health cliff.

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Cutting Calories May Aid Immune System

Immune System Less Affected by Age in Calorie-Restricted Monkeys WebMD 12/4/06 "The study was done by Janko Nikolich-Zugich, MD, PhD, of Oregon Health & Science University, and colleagues. Nikolich-Zugich's group studied 42 monkeys ranging in age from 19 to 23. That's roughly the same as 60 to 70 in humans...The blood tests showed the T-cells of the calorie-restricted monkeys were less affected by age than those of the monkeys on a normal diet...if calorie restriction aids the immune system's T-cells, that might lead to better resistance to infection and, ultimately, to longer life, the researchers note"

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Most Chicken Harbors Harmful Bacteria

83% of Chickens Tested for Consumer Reports Had 1 of 2 Sickening Bacteria WebMD - 12/4/06 "A startling 83% of the chickens tested in a recent Consumer Reports investigation were contaminated with one or both of the leading bacterial causes of food-borne disease -- salmonella and campylobacter...That is up from 49% in 2003, when the group last reported on contamination in chickens...That means always cooking chicken thoroughly, to the point where there are no red juices.
"Chicken needs to be cooked to at least 165 degrees Fahrenheit," Halloran says. "The best thing to do is test it with a meat thermometer. And if you are in a restaurant and you cut into chicken that doesn't look done, send it back.""

If it's not birdflu its bacteria in birds... they have it in for us. But talk about a slide in quality control. Judging by the comments that the industry made, where they are super defensive, could they look any more guilty?

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The Value of a second opinion in medicine

Second Opinion Yields Treatment Changes For Half Of Patients ScienceDaily 12/1/06 "More than half of breast cancer patients who sought a second opinion from a multidisciplinary tumor board received a change in their recommended treatment plan, according to a new study from the University of Michigan Comprehensive Cancer Center...The changes were a result of breast imaging specialists reading a mammogram differently or breast pathologists interpreting biopsy results differently. In some cases, the initial recommendation was changed after the case was reviewed by medical oncologists and radiation oncologists prior to surgery...study author Michael Sabel, M.D., assistant professor of surgery at the U-M Medical School"

So the key is to find a multidisciplinary tumor board and definitely get a second opinion.

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