Monday, January 15, 2007

Pancreatic polypeptide that safely battles obesity

Scientists are looking at whether an appetite-suppressing chewing gum could be used to tackle obesity BBC News 1/15/07 "The Imperial College London team are developing a drug based on a natural gut hormone that mimics the body's "feeling full" response...The hormone in question is called pancreatic polypeptide (PP), which the body produces after every meal to ensure eating does not run out of control...Early tests have shown moderate doses of the hormone, pancreatic polypeptide (PP), can reduce the amount of food eaten by healthy volunteers by 15% to 20%...As well as chewing gum, they believe it could be incorporated in a nasal spray" (Lead researcher Professor Steve Bloom )

Looks like PP is free of side effects. Unlike leptin, our bodies do not develop resistance to PP. And although the hype is that it could be made into a chewing gum
format, or a nasal spray - first it will be used as an injection by prescription. It can't be made into a pill because PP is destroyed in the stomach.

Another amazing part to this story is that Professor Bloom struggled for ages to get funding for this research. A PP prescription might actually be nearing market by now if he had his funding when he first needed it.

More at The Guardian , and The Independent

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